Bicycling tied to reduced dementia risk and greater hippocampal volume retention

A team of geriatricians, neurologists, nutritionists and public health specialists affiliated with a host of institutions across China, working with a pair of colleagues from Australia, has found that of all the transportation modes older people can use to get from one place to another, bicycling appears to offer the most benefit in potentially reducing the chances of developing dementia.

New therapeutic strategy designed to help lower cholesterol levels

When the amount of cholesterol in the blood is too high, hypercholesterolemia can develop, causing serious damage to the arteries and cardiovascular health. Now, a study led by the University of Barcelona and the University of Oregon presents a new therapeutic tool capable of regulating blood cholesterol levels and thus opening up new perspectives in the fight against atherosclerosis caused by the accumulation of lipid plaques in the artery walls.

Pitchers have thicker ulnar collateral ligaments in elbows than other players, factor that risks common injury

Every baseball season, players from major leagues to youth levels lose time because of injuries to the ulnar collateral ligament in their elbow. A University of Kansas researcher is co-author of a new study that used advanced technology to measure the thickness of baseball players’ UCLs, finding the ligaments were thicker in pitchers versus position players and that the common assumption of certain arm slots being less stressful on the elbow was not supported.

Benefits of early biologic treatment in psoriatic arthritis examined in studies

Two studies suggest there is no significant benefit of early biologics over standard step-up care with methotrexate, but these did not select for poor prognosis. The aim, therefore, of the SPEED trial (Severe Psoriatic arthritis—Early intervEntion to control Disease)—was to compare disease activity in 192 PsA patients with poor prognostic factors when treated with one of three regimens: standard step-up with conventional systemic disease-modifying antirheumatic drugs (csDMARD), combination csDMARD, or early induction with a tumor necrosis factor inhibitor (TNFi). The primary endpoint was the mean PsA disease activity score (PASDAS) at 24 weeks. Data were presented at the 2025 annual EULAR congress in Barcelona.

HPV can drive tumor development in rare nasal cancers

Human papillomavirus (HPV) can drive tumor development in some rare sinonasal squamous cell carcinomas (SNSCCs), according to a new comprehensive study of these tumors from investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center. The researchers also identified common mutations among these cancers and a potential combination treatment during the study, which was published in the journal Nature Communications.