Organoids containing blood vessels have been grown, holding promise for research and treatment

For over a decade, scientists have been growing organoids—small clusters of cells that mimic a particular organ—to serve as miniature biological models. Organoids of the brain have been used to study neurodevelopmental disorders; intestinal organoids, to model celiac disease; and lung organoids, to investigate SARS-CoV-2. Heart organoids have even been sent to space to test the effect of microgravity on cardiac muscle. But there’s a tiny problem—the organoids can’t grow any bigger than a sesame seed.

New approach reverses opioid overdoses more safely, rat study shows

Opioid overdoses are a major public health issue in the U.S., killing tens of thousands of people every year. The medicine naloxone, which is available as an over-the-counter nasal spray or given by injection, has saved countless lives by rapidly reversing opioid overdoses. But in blocking opioid receptors in the brain, naloxone causes severe withdrawal symptoms, including pain, vomiting and agitation.

Scientists argue for more FDA oversight of health care AI tools

An agile, transparent, and ethics-driven oversight system is needed for the U.S. Food and Drug Administration (FDA) to balance innovation with patient safety when it comes to artificial intelligence-driven medical technologies. That is the takeaway from a new report issued to the FDA, published this week in the open-access journal PLOS Digital Health by Leo Celi of the Massachusetts Institute of Technology and colleagues.