Jumbled proteins paint a bold target on the backs of brain tumors

Immune therapy has transformed how cancer is treated, but many tumors continue to evade these treatments, thanks to their resemblance to healthy tissue. Now, researchers at UC San Francisco have found that some cancers, like deadly brain cancer (glioma), make unique, jumbled proteins that make them stand out. These newly recognized cancer-specific proteins, or antigens, could speed the development of potent immunotherapies that recognize and attack hard-to-treat tumors.

Methadone treatment shown to improve HIV care for formerly incarcerated individuals

When transitioning from prison to the community, formerly incarcerated individuals face numerous challenges, including lack of employment, housing, and health care. This transition is more precarious for those with HIV or opioid use disorder, who—due to these diseases—have an increased risk of medical complications and even death.

Innovative technology enhances cellular and molecular insights into kidney lesions

Researchers have demonstrated the feasibility of a morphological-based approach to interpreting spatial transcriptomic (ST) data, helping to improve understanding of the lesions that occur in chronic kidney disease (CKD), at both the cellular and molecular levels. A recent study in The American Journal of Pathology, details how this new method could lead to the identification of new biomarkers and therapeutic strategies for patients.