Not all scars are created equal. That’s the conclusion of a new study by Weizmann Institute of Science researchers: They found that two distinct types of scars, referred to as “hot” and “cold,” can form in the diseased heart, and that these two types call for entirely different treatments. As reported today in Cell Systems, the Weizmann study may lead to innovative therapies for preventing or treating heart diseases, and it opens a new line of research on fibrosis—the development of scar tissue in response to injury or during aging—in a variety of other organs.
Mobile prostate cancer screening clinic can ID the disease in disadvantaged men
A “Man Van” deployed in disadvantaged communities can help identify men at high risk for prostate cancer, according to a study presented at the American Society of Clinical Oncology annual Genitourinary Cancers Symposium, held from Feb. 13 to 15 in San Francisco.
Testosterone recovery linked to overall survival in high-risk prostate cancer
Serum testosterone (T) recovery to normal levels is associated with a significant improvement in overall survival in patients with high-risk prostate cancer receiving radiotherapy and long-term androgen deprivation therapy (ADT), according to a study presented at the American Society of Clinical Oncology annual Genitourinary Cancers Symposium, held from Feb. 13 to 15 in San Francisco.
Intra-arterial tenecteplase beneficial for large vessel occlusion
For patients with large vessel occlusion presenting between 4.5 and 24 hours, intra-arterial tenecteplase after successful thrombectomy results in improved likelihood of excellent outcome (modified Rankin scale score 0 to 1), according to a study presented at the annual American Stroke Association International Stroke Conference, held from Feb. 5 to 7 in Los Angeles.
FDA approves tablet form of Evrysdi for spinal muscular atrophy
The U.S. Food and Drug Administration has approved a new drug application for a tablet version of Evrysdi (risdiplam) for people living with spinal muscular atrophy (SMA).
Inflammation may explain how opioid use disorder contributes to preterm birth
Opioid use during pregnancy—whether of highly addictive drugs like fentanyl or controlled opioids like buprenorphine—doubles the risk of preterm birth. A new Yale study reveals that inflammation may be the culprit.
States report zero abortions, sparking debate over data accuracy
In Arkansas, state health officials announced a stunning statistic for 2023: The total number of abortions in the state, where some 1.5 million women live, was zero.
Common osteoporosis treatment drug shows promise against rare type of heart disease
A research team co-led by scientists at the University of Arizona College of Medicine—Tucson found that an osteoporosis drug might counter a rare genetic mutation underlying a type of heart disease. The results were published today in the Journal of Clinical Investigation and could have implications for treating other rare diseases.
mRNA research explores new frontiers in celiac disease treatment
Jax Bari, an 11-year-old from Philadelphia, shows me a photo of himself. It’s hard to look at; in it, he’s sprawled out on the bathroom floor, sad, exhausted. He says, just hours earlier, he had accidentally consumed gluten while out to eat with his family. What followed was hours of vomiting, diarrhea, and stomach pain.
Grid cells’ rhythmic sweeps reshape understanding of brain’s spatial navigation
A discovery at the Kavli Institute at the Norwegian University of Science and Technology (NTNU) in Norway has uncovered a previously unknown function of grid cells, the specialized neurons that help the brain map space.