Multisociety taskforce develops new standards to monitor adults with heart valve disease

The International Consortium for Health Outcomes Measurement (ICHOM) has developed a globally inclusive standard dataset of 16 patient-centered outcome measures for people with heart valve disease, regardless of treatment (surgical or transcatheter procedure), according to a new report published today in the journal Circulation: Cardiovascular Quality & Outcomes.

Antibody therapy shrinks immunotherapy-resistant lung cancer tumors in mice

An investigational therapy significantly shrank lung cancer tumors that are notoriously resistant to treatment by encouraging an attack from natural killer (NK) cells in an animal model, a study led by UT Southwestern Medical Center researchers shows. The findings, published in the Journal for ImmunoTherapy of Cancer, could lead to new types of immunotherapy that rely on this novel strategy.

AI screening for heart failure clinical trial speeds up enrollment, study finds

Artificial intelligence (AI) can rapidly screen patients for clinical trial enrollment, according to a study published in JAMA and led by Mass General Brigham researchers. Their novel AI-assisted patient screening tool significantly improved the speed of determining eligibility and enrollment in a heart failure clinical trial compared to manual screening.

Accelerated drug-testing platform for ALS paves way for therapeutic innovation

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with few treatment options. Since 2018, the Sean M. Healey & AMG Center for ALS at Massachusetts General Hospital (MGH) has been working with national and international stakeholders to accelerate ALS research by launching the first platform trial in ALS to simultaneously test multiple drugs using shared trial infrastructure and placebo data.

Study reveals surge in gambling addiction following legalization of sports betting

A new study, published in JAMA Internal Medicine, led by researchers from the University of California San Diego Qualcomm Institute and School of Medicine, reveals a dramatic increase in sports betting and gambling addiction help-seeking since the landmark Murphy v. NCAA Supreme Court decision in 2018 paved the way for states to legalize sports betting.