The COVID-19 pandemic caused by SARS-CoV-2 infection is marked by excessive inflammation of several organs, leading to multi-organ failure. The recognition of the virus by our bodies triggers severe immune responses, causing a “cytokine storm,” which can lead to acute lung injury and acute respiratory distress syndrome.
Fewer than 500 neurons are associated with the suppression of binge drinking, new research finds
Among the billions of neurons in the brain, fewer than 500 are responsible for suppressing binge drinking, according to new research by Gilles E. Martin, Ph.D., associate professor of neurobiology.
Socioeconomic status linked to white matter changes, which can shape brain heath in later life
A person’s level of social and economic status can shape their brain heath in later life, a study suggests. Research led by the University of Edinburgh found a connection between socioeconomic status and changes in the white matter of the brain—a known risk factor of cognitive decline and dementia in older age.
Stem cell platform aims to recreate brain’s immune system using lab-grown human microglia cells
Microglia are a specialized type of immune cell that accounts for about 10% of all cells within the brain and spinal cord. They function by eliminating infectious microbes, dead cells, and aggregated proteins, as well as soluble antigens that may endanger the brain and, during development, also help shape neural circuits enabling specific brain functions.
Modified CAR-T cells target widespread protein found in multiple types of cancer
CAR-T cells are specialized immune cells genetically modified to recognize and attack cancer cells. Researchers at Nagoya University in Japan and their collaborators have developed new CAR-T cells to target malignant tumors. While similar treatments have worked well for blood cancers, treating solid tumors is more difficult. Their method, published in the Journal for ImmunoTherapy of Cancer, targeted a protein found in high amounts on many types of cancer cells (Eva1), and successfully eliminated tumors in lab mice.
Tuberculosis lesion analysis reveals association between molecular profiles and patients’ clinical indicators
A study in Nature Communications reveals, for the first time, how the transcriptomic profile of human tuberculosis lung lesions is correlated with clinical data from the same patients.
Skip the ice bath if you want bigger muscles, research suggests
Ice baths are everywhere in modern fitness culture. From professional athletes to weekend warriors, many swear by the post-workout plunge, hoping the icy shock will ease soreness, calm inflammation and help their bodies bounce back faster. But recent research from the Netherlands reveals a surprising downside: Those freezing dips might actually slow muscle growth.
BEES: A new mental health tool to track emotional well-being
A simple, short questionnaire designed by an Edith Cowan University (ECU) researcher could help people better understand and track their emotional well-being with minimal time and effort.
Discovery of two new genetic disorders improves diagnoses for patients with neurodevelopmental conditions
The discovery of two new genetic disorders comes from a study delivered through the National Institute for Health and Care Research (NIHR) Manchester Biomedical Research Center (BRC) and The University of Manchester and could provide answers for several thousands of people with neurodevelopmental conditions around the world.
Newborns who survive serious health problems still face a higher risk of dying into adolescence
Infants who survive serious health problems in the first few weeks of life have a higher risk of dying during childhood and adolescence compared to children who were healthy as newborns. This is according to a study from Karolinska Institutet published in the journal JAMA Pediatrics titled “Severe Neonatal Morbidity and All-Cause and Cause-Specific Mortality Through Infancy and Late Adolescence.”