A relatively new therapy used to treat pulmonary arterial hypertension in those with mild to moderate disease was found to be effective at preventing death in those with more advanced disease. Results were published on Wednesday, May 28, in The New England Journal of Medicine and could have “transformative implications” for patients, according to an editorial that accompanied the study written by Bradley Maron, MD, Professor of Medicine and Director of the Hypertension Program at the University of Maryland School of Medicine.
Bladder cancer treatment reprograms bone marrow to boost immune system’s cancer-fighting ability
More than three decades ago, the U.S. Food and Drug Administration (FDA) approved Bacillus Calmette-Guérin (BCG) as the first immunotherapy against cancer. And it is still used today to treat early-stage bladder cancer.
Polycystic ovary syndrome: Awareness improves significantly as health professionals and patients support name change
Most experts and those experiencing the potentially debilitating features of polycystic ovary syndrome (PCOS), which affects one in eight women, want greater awareness and a name change to improve care and outcomes.
Personalized cancer model predicts patient-specific gene behavior, potentially improving survival outcomes
Carnegie Mellon University researchers are using personalized models to decode how cancer behaves in individual patients—revealing hidden subtypes, improving survival predictions and charting a new course for precision medicine.
Mapping the ‘brain in the gut’ may provide clues to gastrointestinal disorders
Researchers at Karolinska Institutet have identified three types of nerve cells connected to the intestinal villi, suggesting that previously unknown neural networks regulate fluid balance in the gut.
Potent CDK9 inhibitor shows promise for overcoming drug resistance in hematological malignancies
A research team has developed a new class of compounds that effectively inhibit both wild-type CDK9 and its drug-resistant mutant form, offering a promising strategy for treating hematological malignancies.
Understanding how Creutzfeldt-Jakob disease hides in neurons for decades
In April 2025, three people in Oregon developed Creutzfeldt-Jakob disease (CJD), a rare, fatal neurological condition that is similar to bovine spongiform encephalopathy, also known as mad cow disease. It impacts one or two people per million each year, making the chances of three cases emerging in the same small geographic area quite low. This outbreak is currently under investigation, but there may not be a simple explanation; for the majority of CJD cases, the infectious source is unknown.
Breast cancer prevention: How nurse practitioners and physician assistants can help
For women at higher risk of breast cancer, there is a proven way to cut the risk in half: take an anti-cancer drug such as tamoxifen.
Anti-malarial medicines can help reduce body weight, researchers discover
In recent years, overweight and obesity have become a serious global health problem, posing significant risk factors for various diseases. Longing for a civilized and healthy lifestyle, more and more people are starting to pay attention to weight loss. Halofuginone (HF), a quinazoline ketone alkaloid found in the roots and leaves of Changshan, might be a new option for obesity treatment.
Developmental delays linked to longer life in fruit flies offer potential model for exploring human longevity
Biologists know that animals that mature slowly tend to live longer, but they aren’t sure why. A recent study of fruit flies by an Iowa State University research team sheds new light on the link between developmental timing and longevity, which could lead to a better understanding of how to lengthen human lives.