All posts by : Felistas

In Brazil, there is still no advanced therapy product for the treatment of chronic wounds and burns that has been registered with health regulatory bodies. A startup based at the Supera Innovation and Technology Park in Ribeirão Preto, in the interior of the state of São Paulo, intends to break down this barrier and become a pioneer in this segment.

In a study estimating the incidence rates of appendiceal adenocarcinoma (AA), or appendix cancer, across birth cohorts in the United States, researchers observed a sharp increase in AA incidence rates for those born after 1945, particularly for Generation X and Millennials. These patterns suggest a timely need for etiologic research and increased AA awareness among physicians and the public.

A new study explains the genetic underpinnings of a rare and aggressive form of ovarian cancer—and offers a potential pathway for new treatments.

Depression and bipolar disorder of late onset may represent more than just mental health conditions. Growing evidence suggests these late-life mood disorders (LLMDs) could be not merely risk factors, but rather early warning signs of neurodegenerative diseases like dementia, even when they appear years before memory loss or other cognitive symptoms become apparent.

Northwestern University biophysicists have developed a new computational tool for identifying the gene combinations underlying complex illnesses like diabetes, cancer and asthma.

Just as folds are important in the ancient art of origami, they are also vital for the function of many proteins. Mutations in a protein associated with conditions such as seizures and autism spectrum disorder prevent it from folding correctly and hinder its movement to the cell surface, where it would normally do its job.

Hepatitis C virus (HCV) infection is highly associated with the development of metabolic dysfunction-associated steatotic liver disease (MASLD), with a diagnosis requiring the presence of steatotic liver disease (SLD) along with at least one of five cardiometabolic risk factors (CMRFs), including obesity, arterial hypertension (HTN), type 2 diabetes (T2D)/prediabetes, and dyslipidemia.

Age-related macular degeneration (AMD) is a major cause of blindness, especially in older adults. A key feature of early AMD is the formation of drusen, clumps of debris made of lipids and proteins that collect between two layers at the back of the eye—the retinal pigment epithelium (RPE) and Bruch’s membrane (BrM).

Researchers from the Biostatistics Unit at the Germans Trias i Pujol Research Institute (IGTP) have led a study, published in BMJ Open, which analyzes how in-hospital mortality evolved during four waves of the COVID-19 pandemic in Catalonia, taking into account the patients’ ceiling of care.

Using a modern imaging technology known as cryo-electron microscopy, researchers at UT Southwestern Medical Center have determined the structure of a protein called midnolin that’s crucial to the survival of malignant cells in some leukemias, lymphomas, and multiple myelomas. Their findings, published in PNAS, provide insight into how this protein functions in cells and could inform the design of new pharmaceuticals that avoid the serious side effects of current therapies.