Ovarian cancer has seen a significant shift in its treatment paradigm with the introduction of poly (ADP-ribose) polymerase (PARP) inhibitors, which are now standard in the maintenance setting following first-line chemotherapy.
A matrix instead of a number: New model reimagines R for infectious disease spread
In 1991, U.S. sociologist Scott Feld wrote, “Your friends have more friends than you do.” Feld’s so-called friendship paradox states that the friends of any given person have more friends on average than the person themselves. This is based on a simple probability calculation: Well-connected people are more likely to appear in other people’s social circles.
Q&A: Researcher discusses identifying new treatments for pediatric brain cancer
Rakesh Jain Ph.D., Director of the E.L. Steele Laboratories for Tumor Biology at Massachusetts General Hospital and A. Werk Cook Professor of Radiation Oncology at Harvard Medical School, is senior author of a new study in PNAS, titled “Targeting EPHB2/ABL1 Restores Anti-Tumor Immunity in Preclinical Models of Ependymoma.”
Boosting protein BCL6 could help GLP-1 users retain muscle while losing fat
About one in eight adults in the United States has tried or currently uses a GLP-1 medication, and a quarter of those users cite weight loss as their main goal. But weight loss doesn’t discriminate between fat and muscle. Patients using GLP-1 drugs can experience rapid and substantial muscle loss, accounting for as much as 40% of their total weight loss. So how can we lose weight without also losing critical muscle?
Inactive today, forgetful tomorrow: The link between lack of physical activity and mental decline
Whenever 27-year-old Nathan Kerr stops by the office of his 81-year-old mentor Frank Booth, Kerr often finds Booth running on a treadmill.
One in 20 adults in England both smoke and vape
Just over one in 20 adults in England both smoke and vape, according to a new study by UCL researchers.
Cracking the code of drug delivery: Using computers and AI to make medicine work smarter
The successful and safe delivery of therapeutics relies on understanding how easily drugs can pass through biological barriers which protect cells.
Blood-brain barrier study reveals insights into neurological disease treatment
Scientists from the University of Liverpool and their global collaborators have highlighted the most effective treatments for neurological diseases by overcoming one of medicine’s most difficult challenges: the blood–brain barrier. Led by Dr. David Dickens, their findings offer new hope for patients with conditions including Alzheimer’s, and Parkinson’s disease, brain tumors, and epilepsy.
Sacklers, Purdue to pay $7.4 bn over opioid crisis: NY state
Several US states have reached a $7.4 billion settlement with the Sackler family and their pharmaceutical company Purdue over the opioid crisis that has ravaged the lives of millions of Americans, officials said Thursday.
Whole-body deodorants: A solution to a non-existent problem
Step into any supermarket or pharmacy, and you’ll find aisles brimming with products designed to make you smell “fresh,” feel “clean,” or somehow achieve a level of “purity” that no human body naturally possesses.