Injectable supramolecular hydrogel shows promise for neoadjuvant immunotherapy of triple-negative breast cancer

The efficacy of immunotherapy against triple-negative breast cancer (TNBC) heavily relies on intratumoral infiltration of cytotoxic T lymphocytes (CTLs). Although neoadjuvant chemotherapy together with immunotherapy has been approved for advanced TNBC, its efficacy is still unsatisfactory, possibly due to systemic treatment-induced lymphatic system disorders and upregulation of additional immune checkpoints in the tumors.

Complete recombination map of the human genome created

Scientists at deCODE genetics/Amgen have constructed a complete map of how human DNA is mixed as it is passed down during reproduction. The map marks a major step in the understanding of genetic diversity and its impact on health and fertility. It continues 25 years of research at deCODE genetics into how new diversity is generated in the human genome, and its relationship to health and disease.

Largest study on the genetics of bipolar disorder to date gives new insights into the underlying biology

Bipolar disorder is a complex psychiatric disorder, characterized by fluctuations between episodes of (hypo)mania and depression. It is estimated to affect around 40 to 50 million people worldwide. The disorder has been linked to a number of negative outcomes, including suicide, and it can take an average of 8 years to get a diagnosis. Yet, little is known about the biology of the condition.