Researchers at University of Tsukuba identified a previously unconfirmed gas exchange threshold in rats and demonstrated that this threshold, together with the lactate threshold, serves as an indicator of moderate-intensity exercise to determine the effectiveness of training in enhancing aerobic performance.
A book on puberty can lead to significant gains in knowledge and positive health outcomes for school-aged girls
Young girls in the New York metropolitan area given a book on puberty and periods were more likely to have increased knowledge related to these topics after reading the book, according to a new study at Columbia University Mailman School of Public Health. The work is published in the journal BMC Public Health.
Team links gene duplications, deletions within chromosome region to nonsyndromic bicuspid aortic valve disease
Large and rare duplications and deletions in a chromosome region known as 22q11.2 , which involves genes that regulate cardiac development, are linked to nonsyndromic bicuspid aortic valve disease, according to a new study led by UTHealth Houston researchers.
New mechanism that shields persister tumor cells from immune system identified
Cancer therapies do not always succeed in eliminating tumor cells. Some of these cells enter a state of senescence—a latent, non-dividing state that is generally irreversible. Others, however, enter a state known as “persistence,” where dormancy is temporary and reversible. This state allows the cells to begin growing again after the treatment has ended, leading to cancer recurrence.
Blood test discovery offers hope for easier asthma diagnosis and care
Scientists at Rutgers Health have discovered that a simple blood test could diagnose asthma and determine its severity, a breakthrough that could transform how the disease is identified and monitored.
Study explores how Tourette syndrome differs by sex
Tourette syndrome is currently diagnosed about three times more frequently in males than in females. A new study finds that female individuals are less likely to be diagnosed with the syndrome, take longer to receive a diagnosis and are older when they are diagnosed than male individuals. The study is published in Neurology.
Combining ctDNA and genomic profiling predicts cancer relapse and treatment response
Researchers from Iwate Medical University and Tohoku University have revealed that it is possible to predict cancer relapse and treatment response by measuring circulating tumor DNA (ctDNA), in tandem with data from comprehensive genomic profiling (CGP). Their study is published in the journal Cancer Science.
Pediatrics study examines the diagnostic potential of microbial cell-free DNA testing
Ear, nose, and throat (ENT) infections are one of the most common reasons for prescribing antibiotics to children. Although some ENT infections can be simple to identify and diagnose, others are more severe and require immediate attention and care.
Exploring novel deep learning-based models for cancer histopathology image analysis
Histopathological evaluation of tumor specimens has long been essential in diagnosing breast cancer and guiding clinical decision-making. However, one of the key challenges in routine diagnostics includes the inter-observer and inter-lab variabilities present in the assessment of prognostic markers that could lead to under- and over-treatment of patients.
Phase III trial finds trastuzumab emtansine improves long-term survival in HER2 breast cancer
In patients with high-risk HER2-positive breast cancer, post-surgery, or adjuvant, treatment with trastuzumab emtansine (T-DM1) reduced the long-term risk of death or invasive disease by 46% and improved survival compared to trastuzumab alone, according to the final results of the Phase III KATHERINE clinical trial led by researchers from the University of Pittsburgh and UPMC Hillman Cancer Center.