Researchers at the Duke Human Vaccine Institute successfully created an HIV vaccine candidate that guides key immune cells along an evolutionary pathway to become broadly neutralizing antibodies.
How one brain circuit encodes memories of both places and events
Nearly 50 years ago, neuroscientists discovered cells within the brain’s hippocampus that store memories of specific locations. These cells also play an important role in storing memories of events, known as episodic memories. While the mechanism of how place cells encode spatial memory has been well-characterized, it has remained a puzzle how they encode episodic memories.
Persistent DNA damage in healthy cells challenges traditional view of mutations
While most known types of DNA damage are fixed by our cells’ in-house DNA repair mechanisms, some forms of DNA damage evade repair and can persist for many years, new research shows. This means that the damage has multiple chances to generate harmful mutations, which can lead to cancer.
A ‘perfect storm’ of mutations: How chronic hepatitis C infection leads to autoimmune disease
Scientists at the Garvan Institute of Medical Research have discovered how a viral infection causes autoimmune disease, disproving a long-standing theory and opening a promising new approach to developing treatments for autoimmune conditions.
Shared pathways between vascular calcification and bone growth offer new therapeutic avenue
Real-time observation of certain biochemical processes in blood vessels from mice has revealed a previously unknown similarity between atherosclerosis, also known as vascular calcification, and bone growth.
DNA methylation mediates the link between childhood adversity and depression, study suggests
Past psychology research suggests that there is a strong relationship between difficult experiences during childhood and the development of depressive symptoms. In fact, statistics suggest that adverse experiences during childhood can double the risk of being diagnosed with depression later in life.
Semaglutide can also be beneficial to people with type 1 diabetes, clinical trial finds
Semaglutide (known by its brand name Ozempic) has gained widespread attention for its weight-loss benefits, but is officially approved for managing type 2 diabetes. While there is currently limited data on its risks and benefits for those with type 1 diabetes, new research offers promising insights.
Choosing mocktails over cocktails could reduce risk of 7 cancers
The U.S. Surgeon General has recommended that alcoholic beverages carry cancer risk warning labels, citing a growing body of research that shows alcohol as a group 1 carcinogen. But more than half of U.S. residents don’t know that alcohol consumption increases their risk of developing cancer, or that it’s the third leading preventable cause of cancer after obesity and tobacco use. A fact health experts hope people will now take more seriously.
Bridging the gap: Models that mirror human tumors in the lab
Researchers in the group of Associate Professor Ninib Baryawno, Department of Women’s and Children’s Health, KI, have published their work, titled “Comparative Single-Cell Transcriptomics of Human Neuroblastoma and Preclinical Models Reveals Conservation of an Adrenergic Cell State,” in Cancer Research.
Ruminating about being lonely is more closely linked to depression than actual loneliness, study suggests
Loneliness is more likely to cause depression if one keeps ruminating on how lonely they are. This is the essence of a study by The University of Hong Kong (HKU) that has therapeutic implications for treating isolated individuals or populations.