Metastatic clear cell renal cell carcinoma (mccRCC), an aggressive type of kidney cancer, has historically presented limited treatment options. Immune checkpoint inhibitors, a form of immunotherapy, can lead to exceptional, durable responses (when the tumor substantially shrinks for a very long period of time) for some patients with mccRRC, allowing them to live longer with a better quality of life. However, the molecular reasons behind these exceptional responses have not been well defined.
Oral glucose-lowering agents are potential alternatives to insulin for gestational diabetes
With respect to the proportion of infants born large for gestational age, treatment of gestational diabetes with metformin and glyburide, if needed, does not meet the criteria for noninferiority versus insulin, according to a study published in the Journal of the American Medical Association.
Talquetamab plus teclistamab shows promise in multiple myeloma
For patients with relapsed or refractory multiple myeloma, talquetamab plus teclistamab shows response in a high percentage of patients and a higher incidence of grade 3 or 4 infections than with either therapy alone, according to a study published in the New England Journal of Medicine.
For women with multiple sclerosis, mobility takes step backward at menopause
A new study by UC San Francisco has found that menopause revs up the progression of multiple sclerosis (MS).
Physical neglect can be as damaging to children’s social development as abuse
While physical neglect is understudied compared to physical, sexual or emotional abuse, neglect is just as damaging to children’s social development, a recent study indicates.
Risk of device failure similar with different peripherally inserted central catheter materials
For patients referred for peripherally inserted central catheters (PICCs), the risk for device failure is not lower with hydrophobic or chlorhexidine PICCs versus standard polyurethane ones, according to a study published in the New England Journal of Medicine.
Electrifying your workout can boost muscles’ mass and strength, study finds
If building strength and muscle mass is part of your New Year’s Resolution, you may want to add a new routine to your workout.
Poor sleep hurts work productivity, survey shows
Got brain fog? Can’t concentrate because you didn’t sleep well—or sleep much at all—last night?
The basis of voluntary movements: Monkey study challenges classical views on how brain controls natural actions
A study published in Science reveals new mechanisms through which the brain controls natural actions. The results challenge some of the classical views about how the motor system works and open up possible new applications in neurorehabilitation and robotics.
Researchers identify risk factors for poor prognosis in alopecia areata
Alopecia areata (AA) is a common autoimmune disease that leads to sudden circular hair loss. The clinical course of AA is unpredictable and varies greatly from individual to individual. Numerous studies have shown that AA is often associated with comorbid, i.e. co-existing, chronic inflammatory diseases, which can have an impact on prognosis and clinical management.