Kidney cancer study identifies factors for exceptional response to immunotherapy

Metastatic clear cell renal cell carcinoma (mccRCC), an aggressive type of kidney cancer, has historically presented limited treatment options. Immune checkpoint inhibitors, a form of immunotherapy, can lead to exceptional, durable responses (when the tumor substantially shrinks for a very long period of time) for some patients with mccRRC, allowing them to live longer with a better quality of life. However, the molecular reasons behind these exceptional responses have not been well defined.

Researchers identify risk factors for poor prognosis in alopecia areata

Alopecia areata (AA) is a common autoimmune disease that leads to sudden circular hair loss. The clinical course of AA is unpredictable and varies greatly from individual to individual. Numerous studies have shown that AA is often associated with comorbid, i.e. co-existing, chronic inflammatory diseases, which can have an impact on prognosis and clinical management.