Two genes linked to common inflammatory arthritis suggest new treatment options

In a first-of-its-kind genome-wide association study (GWAS) researchers have discovered two genes, RNF144B and ENPP1, that cause calcium pyrophosphate deposition (CPPD) disease in Americans of European and African descent. This crystalline arthritis is caused by calcium pyrophosphate (CPP) crystal deposition in joints. The findings of this novel study in the Annals of the Rheumatic Diseases, open up promising new avenues for targeted prevention and treatment of CPPD disease, which are currently lacking.

Study: 1 in 3 youth with mental health crisis spends over 12 hours in emergency department waiting for psychiatric bed

Approximately 1 in 3 pediatric mental health Emergency Department (ED) visits resulting in admission or transfer exceeded 12 hours, and over 1 in 8 exceeded 24 hours, according to estimates based on nationally representative data from 2018 to 2022. Seven in 10 of all kids staying in the ED over 12 hours were there for suicidal thoughts or attempts, and over half for aggressive behaviors.