A new drug for pulmonary fibrosis has reduced disease progression by more than 50% over a 52-week treatment in two clinical trials. Pulmonary fibrosis is a very serious disease, with a life prognosis of 3 to 5 years after diagnosis. But the new drug, nerandomilast (Boehringer Ingelheim), could revolutionize the treatment of the disease after several failures of all potential new drugs tested for this disease in the last decade that have failed in phase 2 or phase 3 studies.
AI-powered framework can predict the evolutionary fitness of SARS-CoV-2 variants
Viral infectious diseases pose significant challenges due to the rapid evolution of viruses through mutations. This was particularly evident during the COVID-19 pandemic, when emerging variants of SARS-CoV-2 sparked new waves of infection. These variants often carry mutations that make them more transmissible, allowing them to spread rapidly across populations.
‘Fast-fail’ AI blood test could steer patients with pancreatic cancer away from ineffective therapies
An artificial intelligence technique for detecting DNA fragments shed by tumors and circulating in a patient’s blood, developed by Johns Hopkins Kimmel Cancer Center investigators, could help clinicians more quickly identify and determine if pancreatic cancer therapies are working.
Effects of blood pressure management on cardiovascular health vary across education levels
The effects of intensive blood pressureā management on rates of cardiovascular events and death vary substantially across individuals’ levels of educational attainment, according to a new study by researchers at the University of Pittsburgh Schools of the Health Sciences and University of Texas at Tyler.
Small molecules in plant-based foods may reduce efficacy of anti-cancer drugs
A Ludwig Cancer Research study has uncovered a surprising link between diet, intestinal microbes and the efficacy of cancer therapy.
First salivary gland regenerative biobank developed to combat chronic dry mouth
Millions of people are affected by chronic dry mouth, or xerostomia, an agonizing side effect of damaged salivary glands. While chemotherapy and radiation treatment for head and neck cancer are the most common causes of this, aging, certain medications and other factors, including diabetes, stroke, Alzheimer’s disease and HIV/AIDS, can also cause chronic dry mouth. Currently, there is no cure for it.
High birth weight found to be leading risk factor for severe birth injury
High birth weight is the main risk factor for birth injuries to the anal sphincter muscles of the person giving birth, according to a study at the University of Gothenburg. This new method for predicting the risks could improve care and reduce injuries.
Generic drugs can be reliably supplied at big savings, study finds
A new study finds that CivicaScript, a not-for-profit drug manufacturer in the US, can reliably supply essential generic medicines at a price that saves patients over 60%, and public and private insurers over 90%, demonstrating the potential of the nonprofit health care utility (HCU) model to deliver a scalable solution to generic drug affordability.
Genomic score predicts patients’ progression to multiple myeloma
A new risk assessment score developed by researchers at Dana-Farber Cancer Institute, the Broad Institute of MIT and Harvard, and Massachusetts General Hospital reveals how multiple myeloma, a form of blood cancer, begins and progresses from precancerous to malignant states by tracing DNA mutations.
Measles is very contagious. Here’s how to avoid it
New Jersey health officials are asking people who went to last week’s Shakira concert at MetLife Stadium to monitor for measles symptoms because a person went to see the singer while infectious.