RNA binding proteins found essential for regulatory T cell function and immune homeostasis

Immunologists from the Institute have been the first to uncover a role for a family of RNA binding proteins in the function of regulatory T cells in the immune system. As their name suggests, regulatory T cells (Tregs) play a key role in modulating the immune system response, regulating the strength of the response by limiting the function of immune effector cells, such as “killer” T cells.

Study examines how a protein called PAX3 controls genes in melanoma

PAX3 is a transcription factor (proteins involved in converting DNA into RNA) that drives melanoma progression by promoting cell growth, migration and survival, while inhibiting cellular terminal differentiation, which is the final stage where a cell becomes specialized and cell division ends. However, known PAX3 target genes are limited and cannot fully explain the wide impact of PAX3 function, suggesting that there are most likely many other genes that PAX3 controls that are undiscovered.

New research highlights health benefits of using heritage art practices in art therapy

Heritage art practices include indigenous and traditional arts practices—such as fiber arts, clay work, distinct painting styles etc.—handed down in families or communities across generations. The fact that they have been sustained for generations, and helped to serve the expressive and psychosocial needs of communities, suggests that they could be ideal approaches to supporting mental health and emotional well-being.

Machine learning model helps identify patients at risk of postpartum depression

Postpartum depression (PPD) affects up to 15% of individuals after childbirth. Early identification of patients at risk of PPD could improve proactive mental health support. Mass General Brigham researchers developed a machine learning model that can evaluate patients’ PPD risk using readily accessible clinical and demographic factors. Findings demonstrating the model’s promising predictive capabilities are published in the American Journal of Psychiatry.