Two studies suggest there is no significant benefit of early biologics over standard step-up care with methotrexate, but these did not select for poor prognosis. The aim, therefore, of the SPEED trial (Severe Psoriatic arthritis—Early intervEntion to control Disease)—was to compare disease activity in 192 PsA patients with poor prognostic factors when treated with one of three regimens: standard step-up with conventional systemic disease-modifying antirheumatic drugs (csDMARD), combination csDMARD, or early induction with a tumor necrosis factor inhibitor (TNFi). The primary endpoint was the mean PsA disease activity score (PASDAS) at 24 weeks. Data were presented at the 2025 annual EULAR congress in Barcelona.
Mapping patient satisfaction across US hospitals reveals Midwest as leading region
A new study analyzing more than 3,200 hospitals across the United States (U.S.) has revealed stark differences in how patients rate their hospital experiences depending on where they receive care. The research was published in PLOS One and led by Man Hung of the University of Utah, U.S., and colleagues.
Scientists shed light on origins of common peanut antibodies in humans
Why do people develop antibodies to food? While clinicians have long observed that healthy humans develop a particular type of antibody, called IgG, to the foods they eat, the reasons for this phenomenon have remained unknown.
Next-generation fitness: New fields promise personalized exercise recommendations
Exercise has been recognized as an extremely effective tool to improve human health—it can have a preventative and even therapeutic effect on non-communicable diseases such as diabetes and cardiovascular diseases.
HPV can drive tumor development in rare nasal cancers
Human papillomavirus (HPV) can drive tumor development in some rare sinonasal squamous cell carcinomas (SNSCCs), according to a new comprehensive study of these tumors from investigators at the Johns Hopkins University School of Medicine and the Johns Hopkins Kimmel Cancer Center. The researchers also identified common mutations among these cancers and a potential combination treatment during the study, which was published in the journal Nature Communications.
Improving maternal outcomes with respectful maternity care
A clinical perspective led by Dr. Kristin Tully and published in Seminars in Perinatology, reveals a critical crisis in U.S. maternity care: Too many women and birthing individuals are suffering preventable harm due to outdated and inequitable practices.
Midea recalls 1.7 million AC units over mold risk
More than 1.7 million window air conditioners are being recalled because of a risk for mold growth, which can lead to serious health problems.
Program helps cancer survivors return to work with confidence
A new pilot project led by McGill University researchers is showing early success in helping cancer survivors return to work, addressing an aspect of recovery they say is often overlooked.
FDA plans to use AI to speed up drug and food safety reviews
The U.S. Food and Drug Administration (FDA) says it plans to use artificial intelligence (AI) to help speed the approval of new drugs and medical devices.
Should you let pets sleep next to you? (Does it even matter what the experts say?)
It turns out, our furry best friend might be our sleep enemy.