Study helps explain how laughing gas could fight treatment-resistant depression

Although a plethora of medications and therapies now exist for major depression, roughly one in three diagnosed patients still suffer from treatment-resistant depression (TRD)—a form of the disorder that does not respond to first-line antidepressants. Even when traditional drugs work, they often take weeks to kick in, delaying relief for people in crisis.

Do vowels have colors? According to some with synesthesia, yes.

It’s hard to pinpoint when synesthesia, the rare neurological condition where a stimulus that affects one sense prompts a response in a different sense, was first documented. Scientific literature marks its beginning in 1812, when it appeared as an aside in a Bavarian medical student’s dissertation. Toward the end, there’s a small section where he detailed how he associated musical tones and letters with colors.

A failed fragile X syndrome drug can reduce cocaine use, clinical trial finds

A team of pharmaceutical researchers at Novartis Biomedical Research, working with an international team of associates, has found that the drug mavoglurant can reduce use in people with cocaine use disorder. In their study, published in the journal Science Translational Medicine, the group conducted a Phase II clinical trial with 68 people with a diagnosed cocaine use disorder.