Earlier this year, the U.S. Food and Drug Administration (FDA) proposed a new rule to limit nicotine in cigarettes and certain other tobacco products, like cigars and pipe tobacco, bringing nicotine down to minimal or nonaddictive levels. If finalized, this change would be a major step in addressing the public health concerns of smoking and tobacco use in the United States.
Novel Alzheimer’s drug candidate reduces inflammation and protects neurons
Alzheimer’s disease, the most common cause of dementia, is currently incurable. The current drugs available have very limited efficacy and only in mild stages of the disease. A team from the University of Barcelona has developed a promising therapeutic candidate to treat this disease, which affects more than 800,000 people in Spain.
Machine learning helps predict immunotherapy response in lymphoma patients
Researchers with City of Hope and Memorial Sloan Kettering (MSK) Cancer Center have created a tool that uses machine learning to assess a non-Hodgkin lymphoma (NHL) patient’s likely response to chimeric antigen receptor (CAR) T cell therapy before starting the treatment, according to study results published in Nature Medicine.
SOX9 as a prognostic marker in gastric adenocarcinoma
Gastric cancer (GC) is a leading cause of cancer-related deaths worldwide, with more than one million new diagnoses annually. Unfortunately, many cases are detected at advanced stages due to the lack of clear early symptoms, making effective treatment more difficult.
Implant-derived metals found in cerebrospinal fluid
Research led by Charité–Universitätsmedizin Berlin has found that metal particles from artificial joint implants can enter the central nervous system and accumulate in cerebrospinal fluid, raising concerns about potential neurological effects.
Vision restored: Retinal therapy research marks first successful induction of long-term neural regeneration
Vision is one of the most crucial human senses, yet more than 300 million people worldwide are at risk of vision loss due to various retinal diseases. While recent advancements in retinal disease treatments have successfully slowed disease progression, no effective therapy has been developed to restore already lost vision—until now.
Unintentional drug overdoses take a disproportionate toll across the US, study finds
A recent study from Columbia University’s Mailman School of Public Health reveals significant racial and sex disparities in drug overdose mortality rates. The research found that both Black men and Black women have been disproportionately impacted by overdose deaths, with their mortality rates rising sharply compared to their white counterparts.
AI eye scans could help doctors identify heart disease and stroke risk
A new study has for the first time tested the use of an artificial intelligence–powered eye scan in general practice clinics to screen patients for cardiovascular disease.
4:3 intermittent fasting shows modestly greater weight loss than daily caloric restriction
A randomized clinical trial compared the effects of 4:3 intermittent fasting versus daily caloric restriction on weight loss when combined with comprehensive behavioral support in adults with overweight or obesity. The data showed that 4:3 intermittent fasting resulted in modestly greater weight loss over 12 months. The results are published in Annals of Internal Medicine.
Combination immunotherapy shrinks a variety of metastatic gastrointestinal cancers in clinical trial
A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment’s effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH).