Zebrafish research highlights protein Wdr5’s role in preventing blood cell DNA damage

A study led by Prof. Liu Feng from the Institute of Zoology of the Chinese Academy of Sciences has identified a crucial role for the tryptophan-aspartic acid (WD) repeat protein 5 (Wdr5) in maintaining the survival and genomic integrity of hematopoietic stem and progenitor cells (HSPCs) during embryonic development. The findings were published in the Proceedings of the National Academy of Sciences.

Spreading and clotting of platelets shown to be regulated by separate pathways

When skin is cut or damaged, tiny cell fragments circulating in the blood, called platelets, arrive at the injury and spread out to stop the blood from leaking out. Once enough layers of platelets accumulate, like stacks of sandbags against a flood, a blood clot is formed, trapping red blood cells. When the break occurs in a blood vessel, the clot contracts to facilitate smooth blood flow through the vessels.

Epigenetic markers: A promising approach to predicting cardiometabolic disease risk

A new study explores how epigenetic markers—chemical modifications that influence gene activity—can help predict the risk of developing cardiometabolic diseases and guide personalized prevention strategies. The findings are particularly significant as the prevalence of major cardiometabolic risk factors such as hypertension, diabetes, and obesity continues to rise despite advancements in health care and treatment. This trend highlights the need for better early detection and intervention.