Researchers have found a potential new way to slow the progression of lung fibrosis and other fibrotic diseases by inhibiting the expression or function of Piezo2, a receptor that senses mechanical forces in tissues including stress, strain, and stiffness. The new study published in The American Journal of Pathology sheds light on the underlying mechanisms of pulmonary fibrotic diseases and identifies potential new targets and options for therapy to improve patients’ outcomes.
Prostate cancer is the second-leading cause of cancer deaths in American men. Further, non-Hispanic Blacks have a higher incidence of prostate cancer and are more likely to die from it than are non-Hispanic whites. A biopsy is recommended if a patient has certain risk factors like age, family history, symptoms and screening test results. When the biopsy sample is taken, physicians use either ultrasound or magnetic resonance imaging (MRI) to guide the procedure.
A drug typically prescribed for arthritis halts brain-damaging seizures in mice that have a condition like epilepsy, according to researchers at the University of Wisconsin–Madison.
A Japanese research team has discovered a novel global cooperative phenomenon of cell interactions in cervical cancer cells. Their findings suggest that the cells are metabolically connected in a functional network. The framework they used in their studies could prove useful for investigating the hidden state of a group of cells.
People who have had COVID-19, even mild cases, tend to have cardiovascular imbalances in the short and medium term and need to undergo rehabilitation. This was the finding of a study of 130 volunteers conducted at the Federal University of São Carlos (UFSCar) in Brazil.
For human health, prematurely aging cells are a big problem. When a cell ages and stops growing, its function changes, which can cause or worsen cardiovascular disease, Alzheimer’s disease and other chronic diseases. But these cells are also like needles in a haystack, difficult to identify by traditional scientific measures.
A new study provides a unique insight into the group seeking gender-affirming care in Sweden. It shows that transgender people are a socioeconomically vulnerable group and that in 2020, 0.07% of Sweden’s population had received a gender incongruence diagnosis, while 0.03% had undergone a legal gender change.
Infectious disease outbreaks have a bad habit of piling on at the worst possible times.
Congenital heart disease (CHD) is one of the most common birth defects, but the full extent of its genetic underpinnings has been a mystery. Now, a new study of more than 11,000 children with CHD identifies 60 genes that are mutated in CHD patients more often than expected by chance.
Cornell researchers have confirmed that a previously identified biomarker for detecting the presence of malignant testicular germ cell tumors—the most common solid cancers in young men—has the potential to improve patient outcomes through early detection, possibly even prenatally.