Immune cell dysfunction in GI tract may lead to onset of inflammatory bowel disease

A research team led by Mount Sinai has uncovered mechanisms of abnormal immune cell function that may lead to Crohn’s disease, according to findings published in Science Immunology. The researchers said their discovery provides a better understanding of disease development and could inform the development and design of new therapies to prevent inflammation before it starts in the chronic disorder.

Study reveals a key mechanism for controlling the activity of neuronal identity regulators

A team of researchers has identified a mechanism that regulates the production of two different proteins from the same gene. Researchers from the Institute for Neurosciences, a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche, in collaboration with researchers from Columbia University (New York, U.S.) carried out their study with the nematode C. elegans, a small worm widely used in biological research as an animal model.

Glioblastoma trial design is expanding and becoming more suited to clinical practice

Researchers at the University of Tsukuba have investigated the changes in the primary evaluation items in phase II clinical trials for glioblastoma, a type of brain tumor. Recently, the items have become more diverse, with more time-to-event indicators such as survival time being used, whereas the use of response rate, which indicates the proportion of patients whose cancer has shrunk, has decreased. These changes indicate that the design of trials is becoming more comprehensive and more adapted to clinical practice.