Adolescents engaged in fewer external risky behaviors but some report increasing mental health concerns

Between 1999–2021, U.S. adolescents steadily desisted from risky behaviors such as substance use and violence, and from reporting a combination of both risky behaviors and mental health symptoms. Yet a comparatively small but growing proportion of youth demonstrated elevated symptoms of depression, according to a report to be published in the April 2025 issue of Pediatrics.

‘Flycode’ system allows simultaneous analysis of 25 antibodies in mice to reduce animal testing

Many modern drugs are based on antibodies. These proteins very specifically identify a certain structure on the surface of cells or molecules and bind onto it—this may be a receptor protruding from the cell envelope. For antibodies and other protein-based biotherapeutics, extensive preclinical tests need to be conducted on animals before they can be tested on humans.

Dialysis drug shows promise for combating antibiotic resistance in the gut

Increased antibiotic use can lead, seemingly paradoxically, to more problematic infections, as the bacteria evolve to resist the treatment. The answer to this antimicrobial resistance, which the Centers for Disease Control and Prevention called “one of the world’s most urgent public health problems,” might be a medication used for kidney disease, according to a team led by researchers at Penn State.