Innovative in vivo imaging offers new treatment, hope for sufferers of chronic TMJ-related pain

A groundbreaking study has uncovered new insights into the pain pathways associated with temporomandibular joint (TMJ) disorders. Using an innovative in vivo imaging tool to capture functional activity in mouse models of TMJ injury and inflammation, the discovery could pave the way for more effective treatments for the millions affected by TMJ-related facial pain.

Researchers find novel mechanisms in rare childhood epilepsy

Investigators in the laboratory of Gemma Carvill, Ph.D., assistant professor in the Ken and Ruth Davee Department of Neurology Division of Epilepsy/Clinical Neurophysiology, have discovered novel mechanisms underlying Dravet syndrome, a rare genetic form of epilepsy in children, that may serve as promising therapeutic targets, according to findings published in JCI Insight.

New immunotherapy strategy targets macrophage receptors to enhance melanoma treatment

Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO. Their study, published in the Journal for ImmunoTherapy of Cancer, shows that blocking MARCO in combination with a type of immunotherapy known as anti-CTLA4 therapy, significantly enhances tumor regression in melanoma, the deadliest form of skin cancer.

Study finds racial and ethnic disparities in air quality monitor locations in the US

U.S. Environmental Protection Agency (EPA) air quality monitors are disproportionally located in predominately white neighborhoods, according to University of Utah research. The EPA’s network consistently failed to capture air quality in communities of color across six major pollutants, particularly lead and sulfur dioxide, followed by ozone and carbon monoxide.