Novel spatial immune-based risk prediction platform can predict hepatocellular carcinoma recurrence

A research team led by Prof. Sun Cheng from the University of Science and Technology of China (USTC), in collaboration with researchers from the Agency for Science, Technology and Research and Chinese Academy of Agricultural Sciences, has successfully developed a novel spatial immune-based hepatocellular carcinoma (HCC) recurrence risk prediction platform.

Preclinical study demonstrates improved gene therapy approach to treating a rare and devastating disease in children

In a preclinical study, researchers at Children’s Hospital of Philadelphia (CHOP) demonstrated a novel gene therapy with potentially increased effectiveness and safety for the treatment of metachromatic leukodystrophy (MLD), a rare disease in young children characterized by the deficient activity of a critical enzyme. Without effective treatment, MLD leads to rapidly declining neurological skills in young children and is potentially fatal. The promising findings were published in print today in the journal Molecular Therapy Nucleic Acids.

Tecovirimat is safe but ineffective as treatment for clade II mpox

The antiviral drug tecovirimat used without other antivirals did not reduce the time to clinical resolution of clade II mpox lesions or improve pain control among adults in an international clinical trial sponsored by the National Institutes of Health (NIH). The trial enrollment was stopped in late 2024 when an interim analysis showed that tecovirimat monotherapy was ineffective in the study population. Detailed results were presented at the 2025 Conference on Retroviruses and Opportunistic Infections (CROI) in San Francisco.

Neutralizing antibodies for treating hepatitis E in high-risk patients identified

Infections with the hepatitis E virus often go unnoticed because they cause no symptoms. However, in patients with a weakened immune system or existing liver damage and also in pregnant women, the virus can cause severe liver inflammation, which can be fatal. Despite existing therapeutic approaches, there are currently no authorized specific treatment options.

What do we mean by ‘brain health’ and why should you care about it?

The average adult brain only weighs about 3 pounds, yet it is one of the most complex and vital organs of the human body. Cognition may decline and our brains become prone to disease as we age, so as medical advances and other factors help the world’s population live longer the prevalence of brain disease, including dementia, is on the rise. However, keeping our brains healthy may be easier than people realize with some helpful guidance from the American Heart Association, a global force changing the future of health of all.