A breakthrough in lung cancer treatment may be on the horizon. Scientists at VCU Massey Comprehensive Cancer Center have uncovered a powerful combination therapy leveraging sotorasib—an FDA-approved drug in the market—and an experimental drug called FGTI-2734, which could make precision medicine more effective for patients with a highly resistant form of lung cancer. The study, featured on the cover of the Journal of Thoracic Oncology, reveals a potential game-changer for patients battling tumors with the KRAS G12C mutation—a driver in about 14% of non-small cell lung cancers.
Machine learning model predicts PTSD symptom severity over time
The severity of symptoms in posttraumatic stress disorder (PTSD) varies greatly across individuals in the first year after trauma and it remains difficult to predict whether someone might worsen, improve, or recover.
Reproductive justice-driven pregnancy interventions can improve mental health
Perinatal interventions guided by reproductive justice principles can have positive effects on the perinatal mental health of Black birthing patients and, perhaps, the mental health development of their infants, states a systematic review published in a special issue of Harvard Review of Psychiatry.
Impact of chronic kidney disease escalates around the world
The impact of chronic kidney disease (CKD) keeps escalating around the world, and this burden is projected to rise with population growth and aging, according to a study published in BMC Public Health.
More diverse investigators could help diversify clinical trials
Black Americans are more willing to participate in medical studies led by Black doctors and researchers, perceiving them as more trustworthy, finds a new study co-authored by a Cornell economist.
Study confirms link between breast density, higher breast cancer risk
A new study confirms that breast density plays a significant role in both the risk of breast cancer diagnosis and the sensitivity of mammography, which may affect screening practices.
Upper urinary tract cancer drug may offer long-term benefits
While randomized comparative trials are needed, a relatively new treatment option for upper urinary tract cancers shows promise for lowering long-term recurrence in many patients with low-grade disease, according to a multicenter study led by researchers at UT Southwestern Medical Center.
Curing Alzheimer’s disease: Magic bullet or magic shotgun blast?
Why are researchers still fumbling in the quest to cure what is arguably one of the most important diseases confronting humankind—Alzheimer’s disease? Despite decades of research, there is still no curative treatment for Alzheimer’s—no “magic bullet” that stops this devastating degenerative brain disease in its tracks.
How can parents talk to their kids about Cyclone Alfred?
Cyclones and floods are terrifying and unpredictable. The stress of ensuring your family’s safety, worrying about what might happen and then coping with the aftermath can feel overwhelming.
Researchers revive decades-old pregnancy cohort with modern scientific potential
The Camden Study, a pregnancy cohort of 4,765 women recruited between 1985 and 2006 from one of America’s poorest cities, has found new life at Rutgers University—where it promises to unlock critical insights into maternal and child health for researchers worldwide.