Preclinical Alzheimer’s disease: Study finds faster tau accumulation in females

An international team of researchers, led by Massachusetts General Hospital and Harvard Medical School, has conducted a meta-analysis revealing that women with high β-amyloid (Aβ) exhibit significantly faster tau accumulation in key brain regions compared to men. Findings suggest that sex differences in Alzheimer’s disease (AD) pathology may influence treatment efficacy, prompting a need for sex-specific therapeutic strategies.

Newly discovered biomarkers could improve endometrial cancer treatment

Researchers at the Icahn School of Medicine at Mount Sinai have made an important discovery that could help doctors choose better treatments for patients with recurrent endometrial cancer. Their study, published in the Journal for ImmunoTherapy of Cancer, found specific proteins in the blood (biomarkers) that may predict how well a patient will respond to a combination of two cancer drugs, cabozantinib and nivolumab.

New insights into insulin action: Dynamic signaling network offers therapeutic approaches for type 2 diabetes

Researchers from the German Diabetes Center (DDZ) and the Heinrich Heine University Düsseldorf (HHU) have studied the temporal pattern of insulin action on protein kinases in human muscle cells in detail for the first time. Their findings have been published in the journal Nature Communications and reveal previously unknown mechanisms that could be used to treat type 2 diabetes.

White blood cells use brute force to dislodge bacteria, study shows

A vivid new image is taking shape in the world of cell biology: Imagine bacteria adhering to the surface of a cell, perhaps at the site of an injury or wound. In response, a white blood cell arrives at the scene. This cell encircles the pathogen with its membrane, forming a tight, constricting ring. With remarkable force, the white blood cell yanks the pathogen off the wound’s surface. The white blood cell then engulfs the pathogen in a process called phagocytosis, in which it “eats” the foreign invader to neutralize it.

First clinical RNA sequencing test promises enhanced genetic diagnostics

RNA sequencing has emerged as a powerful supplement to DNA sequencing for Mendelian disease diagnosis, but clinical translation of diagnostic RNA-seq has not been widely achieved. Researchers at Baylor College of Medicine’s Medical Genetics and Multiomics Laboratory have published the clinical validation of the first RNA sequencing test for diagnostic whole-transcriptome analysis for genetic disorders.