Five-year-old Shado is one of dozens of children being rushed to a health center in the US state of Texas to get the measles vaccine, after the recent death in the area of a child who was not immunized against the highly contagious virus.
Gene therapy developed for maple syrup urine disease shows promise
A study led by UMass Chan Medical School researchers has demonstrated that a gene therapy to correct a mutation that causes maple syrup urine disease (MSUD) prevented newborn death, normalized growth, restored coordinated expression of the affected genes and stabilized biomarkers in a calf as well as in mice.
Large population study identifies long-term health risks after COVID-19 hospitalization
A French nationwide study has revealed that survivors of COVID-19 hospitalization face an increased risk of death or organ-related disorders for up to two-and-a-half years after discharge.
Fat transport deficiency explains rare childhood metabolic crises
Researchers studying a protein linked to a rare, severe disease have made a discovery that sheds light on how cells meet their energy needs during a severe metabolic crisis. The findings could lead to new treatments for the disease and open new avenues of research for other conditions involving impaired fat metabolism.
Critical illness is more common than expected in African hospitals, but low-cost treatments offer hope
One in eight patients in hospitals in Africa is critically ill, and one in five of the critically ill die within a week, according to a study appearing in The Lancet. The researchers behind the largest study of critical illness in Africa to date conclude that many of these lives could have been saved with access to cheap life-saving treatments.
Neuroengineering decodes facial and muscle signals, restoring voices and identity
Lee Miller vividly recalls the day in 2021 when he met a woman who had lost the function of her vocal cords. In hoarse, whispering tones, she explained how her voice had been instrumental to her vocation. Losing it, she said, undercut her life’s purpose. Her words were faint, but the lesson was powerful.
Scientists discover the function of a mysterious HIV component
Researchers from the Max Planck Institute of Biochemistry have discovered the mechanism behind an important step in the life cycle of HIV. Working together with teams at Heidelberg and Yale Universities, they found that the enigmatic “spacer peptide 2,” one of the virus components, plays a key role in converting immature HIV-1 particles into infectious particles. The results of the study were published in the journal Nature.
How air pollution and wildfire smoke may contribute to memory loss in Alzheimer’s disease
Air pollution contributes to nearly 7 million premature deaths each year, and its effects go far beyond the lungs. Breathing in wildfire smoke or automobile-related city smog doesn’t just increase the risk of asthma and heart disease—it may also contribute to brain diseases as diverse as Alzheimer’s and autism.
Innate immune training aggravates inflammatory bone loss in experimental models
Clinical research has long focused on ways to harness the actions of the immune system. From vaccines to immunotherapies, researchers have used their knowledge of the immune system to develop therapies to treat or prevent diseases from influenza to autoimmune disease and cancer.
Discovery of lung-based blood stem cells may transform transplant therapies
Red blood cells carry oxygen from the lungs to every other organ, and blood-forming stem cells must make about 200 billion new red blood cells each day to keep the oxygen flowing.