Pilot study suggests senolytic medications may boost cognition in Alzheimer’s risk group

A new pilot study known as STAMINA (Senolytics To Alleviate Mobility Issues and Neurological Impairments in Aging), that focused on the effects of senolytic medications, Dasatinib and Quercetin (DQ), which remove old (senescent) cells from the body, suggests that intermittent treatment may hold promise for improving cognitive function in older adults at risk of Alzheimer’s disease.

How the brain builds sophisticated maps to navigate and remember the world

The brain creates internal “maps” to help us navigate and learn from our surroundings, but how these maps form remains a challenge to understand. Now, a study led by Liset M. de la Prida at the Cajal Neurosciences Center (CNC-CSIC) in Madrid, in collaboration with Imperial College London, offers a fresh perspective on how spatial and experiential information is encoded in the hippocampus, a key brain region for navigation and memory.

Obinutuzumab efficacious for renal response in lupus nephritis

For patients with active lupus nephritis, obinutuzumab, a humanized type II anti-CD20 monoclonal antibody plus standard therapy is more efficacious for providing a complete renal response than standard therapy alone, according to a study published online Feb. 7 in the New England Journal of Medicine. The research was published to coincide with the International Society of Nephrology annual World Congress of Nephrology, held from Feb. 6 to 9 in New Delhi.