Plummeting immunization rates, outbreaks of once-vanquished childhood diseases, and the appointment of a vocal vaccine skeptic as health secretary have US experts sounding the alarm about a looming public health crisis.
Substantial portion of cancer patients in early trials access drugs that are later approved, study finds
A paper in the Journal of the National Cancer Institute finds that almost 20% of patients in middle-stage cancer drug trials receive treatment that eventually proves effective enough to get FDA approval. This may have important implications for drug development and clinical trial recruitment.
Melatonin supplementation may help offset DNA damage linked to night shift work
Melatonin supplementation may help offset the DNA damage associated with night shift work by boosting the body’s ability to repair it, suggest the findings of a small clinical trial published online in the journal Occupational & Environmental Medicine.
Common gynecological disorders linked to raised heart and cerebrovascular disease risk
Having one or more common gynecological disorders, such as endometriosis or heavy or irregular periods, may be linked to a heightened risk of heart disease and conditions that affect blood flow to the brain (cerebrovascular disease), finds a pooled data analysis of the available evidence published online in the journal Heart.
Novel cigarette pricing policy linked to decrease in sales in California city
A recent study has found that an Oakland, Calif. law requiring cigarette prices to increase to a minimum of $8 per pack led to a decline in sales, suggesting that these minimum floor price laws could complement tobacco taxation to reduce smoking rates.
Study: Childhood trauma and neighborhood disorder impact mental health of injured Black men
A new Penn Nursing study published in the Journal of Urban Health reveals that both Adverse Childhood Experiences (ACEs) and perceived neighborhood disorder significantly impact the mental health of Black men in Philadelphia following serious traumatic injuries. The Penn Nursing study highlights the critical role of social and environmental factors in post-injury recovery.
Study finds 1 in 5 infectious disease doctors infected in 2020
Medical doctors in infectious disease clinics were significantly more likely to be infected with the SARS-CoV2 virus than doctors with less patient contact. This is shown in a new study at Umeå University. One in five doctors working in infectious disease clinics were infected during the first and second waves of the pandemic in 2020.
Herpesviruses may contribute to Alzheimer’s disease via transposable elements
Researchers from Cleveland Clinic’s Genome Center have outlined the pathway human herpes simplex virus-1 (HSV1) can use to contribute to Alzheimer’s disease in aging brains. In a report published in Alzheimer’s & Dementia, investigators also share two FDA-approved, commercially available drugs that reverse this pathway in a laboratory setting.
Underlying mechanisms of age-related dysfunction in glands crucial to eye function identified
A team led by Mount Sinai researchers has identified stem cell populations and mechanisms underlying age-related degeneration in glands that are vital to eye function. The findings, published in Nature Communications on February 15, may lead to new therapeutic approaches for evaporative dry eye disease, a common condition in older people.
AI may aid in timely diagnosis of schizophrenia and bipolar disorder
Schizophrenia and bipolar disorder are severe mental disorders that often manifest in early adulthood. Effective treatments exist, but they require an accurate diagnosis—something that is more challenging than one might expect.