Blood metabolite patterns may indicate severity of gestational hypertension and preeclampsia

Preeclampsia, a complication of pregnancy characterized by high blood pressure and high levels of protein in the urine (proteinuria), indicating damage to the kidneys or other organ damage, is the main cause of maternal-fetal death in Brazil and the runner-up worldwide. In a Brazilian study published in the journal PLOS ONE, the pattern of substances present in patient blood samples varied according to the severity of the preeclampsia concerned.

Novel PET tracer reveals potential for recovery in spinal cord injuries

A novel PET technique that visualizes spinal cord injuries provides critical information about which patients may be able to regain mobility, according to new research published in the February issue of The Journal of Nuclear Medicine. By detecting intact nerve connections in the injured spinal cord, a newly developed radiotracer has the potential to help diagnose injuries more precisely, monitor recovery, and evaluate the effectiveness of new therapies in clinical trials.

Stealth virus: How Zika builds tunnels to covertly infect cells of the placenta

Infection with Zika virus in pregnancy can lead to neurological disorders, fetal abnormalities and fetal death. Until now, how the virus manages to cross the placenta, which nurtures the developing fetus and forms a strong barrier against microbes and chemicals that could harm the fetus, has not been clear. Researchers at Baylor College of Medicine with collaborators at Pennsylvania State University report in Nature Communications a strategy Zika virus uses to covertly spread in placental cells, raising little alarm in the immune system.

Packing lipid nanoparticles with tumor proteins to boost cancer vaccine potency

The concept of using vaccines to treat cancers has been around for several decades. A vaccine was first approved for prostate cancer in 2010, and another was approved in 2015 for melanoma. Since then, many therapeutic—as opposed to preventive—cancer vaccines have been in development, but none are approved. One hurdle is the difficulty in finding antigens in tumors that look foreign enough to trigger an immune response.

How genetics shape blood proteins during development from childhood to adolescence

Blood proteins serve as crucial indicators of health and disease risk throughout development. Now, researchers at the University of Copenhagen and the Max Planck Institute of Biochemistry have revealed how these proteins are regulated during childhood and adolescence, providing a vital foundation for understanding disease mechanisms and developing better diagnostic tools.