Exercise can restore STAT3 levels in the amygdala, preventing stress-induced high blood pressure

Hypertension (high blood pressure) is a debilitating condition and a major cause of premature death worldwide. Chronic stress plays a significant role, but the underlying mechanism involving biochemical pathways by which stress leads to hypertension has not been well understood. Understanding these pathways could lead to the development of therapeutic agents to combat hypertension.

Study reveals diverse progression in mitochondrial DNA deletion syndromes

Researchers from the Mitochondrial Medicine Program at Children’s Hospital of Philadelphia (CHOP) have better characterized a spectrum of what were classically considered discrete mitochondrial DNA deletion disease syndromes. The findings offer new insights into genetic causes, potential symptoms, and disease progression, and may inform future clinical trial development. The findings were published today in the journal Genetics in Medicine.