Genetically diverse mouse models reveal eye aging patterns and brain health clues

Vision changes are an inevitable part of aging, but why are some more susceptible to age-related eye diseases and why do some individuals experience more severe decline than others? New research from The Jackson Laboratory (JAX) reveals that genetics play a key role in how the eye ages, with different genetic backgrounds influencing retinal aging in distinct ways.

Sex differences in heart cells may influence disease outcomes

Heart disease is the number one killer of men and women, but it often presents differently depending on sex. There are sex differences in the incidence, outcomes, and age of onset of different types of heart problems. Some of these differences can be explained by social factors—for example, women experience less-well recognized symptoms when having heart attacks, and so may take longer to be diagnosed and treated—but others are likely influenced by underlying differences in biology.

Neurons linked to empathy: Study reveals brain cells that help us understand others

Researchers at Washington University in St. Louis Medicine Mallinckrodt Institute of Radiology have identified specific neuronal cells that are essential to our understanding of other people. Runnan Cao, Ph.D., an instructor in radiology and former postdoctoral fellow in the lab of Shuo Wang, Ph.D., an associate professor of radiology, identified more than 700 such neurons in the human brain. These cells are involved in “social inference,” our ability to read cues from other people’s body language and expressions to draw conclusions about what they are feeling or thinking.