A high-resolution ‘map’ reveals the structural and functional complexity of endogenous NMDA receptors in the brain

In a study published in Cell, a research team led by Zhu Shujia from the Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences (CAS), along with Li Yang from the Shanghai Institute of Materia Medica of CAS, has dissected the assembly and architecture of endogenous N-methyl-á´…-aspartate receptors (eNMDARs) in the adult mammalian cerebral cortex and hippocampus.

Brain receptor study offers hope for preventing epilepsy after traumatic brain injury

A new international study has unveiled critical insights in understanding post-traumatic epilepsy (PTE), a condition that can develop following traumatic brain injury. Published in Theranostics, the study highlights the important role played by a receptor in the brain called P2X7. It suggests how we could both reduce epilepsy risk and predict which patients are most at risk of developing PTE by targeting this receptor.

Study: Among veterans with alcohol use disorder, women drink as much as men and have more severe mental health symptoms

Women veterans with alcohol use disorder (AUD) are drinking in similar quantities to their male peers and have more severe symptoms of co-occurring depression, anxiety, and PTSD, a new study suggests. Among veterans, the rates of AUD and related impairments in physical and mental functioning are higher than in the general population. The study in Alcohol, Clinical & Experimental Research implies that drinking trends among veterans are paralleling those in the general population.

Analysis tackles the question of how many attempts it takes to quit different substances

Relapse is common when someone is trying to quit, regardless of whether they’re giving up opioids or alcohol or cigarettes. To better inform treatment, researchers with the Fralin Biomedical Research Institute at VTC’s Addiction Recovery Research Center wanted to better understand how the experience of quitting differed across substances.