How the chemotherapy drug sorafenib triggers muscle wasting through cell remodeling

Chemotherapeutic agents are often used to treat cancer. They combat tumor growth, but also have a number of undesirable side effects. One of these is severe muscle wasting, known as chemotherapy-induced cachexia. This chronic disease causes uncontrollable breakdown of fat and muscle tissue as well as weight loss. However, in order to improve treatment strategies, the molecular basis must first be understood.

Marginalized patients more likely to still take daily aspirin despite risks

The prevalence of daily low-dose aspirin use fell significantly after the American College of Cardiology and the American Heart Association narrowed recommendations in 2019. However, new research published Jan. 22 in JAMA shows that message has not reached all population segments equally, leaving some groups at greater risk of adverse effects like gastrointestinal bleeding and intracerebral hemorrhage.