A first-of-its-kind clinical trial shows that therapeutic plasma exchange (TPE) combined with intravenous immunoglobulin reduced biological age on average by 2.6 years, as measured by multi-omic biomarkers. Results of the single-blind, placebo-controlled trial are published in Aging Cell.
ASCO: GLP-1 receptor agonists may reduce risk for obesity-related cancer, all-cause death
For adults with diabetes and obesity, glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are associated with a reduced risk for obesity-related cancer compared with dipeptidyl peptidase-4 (DPP-4) inhibitors, according to a study scheduled to be presented at the annual meeting of the American Society of Clinical Oncology, held from May 31 to June 4 in Chicago.
How your country’s culture could affect your mental health recovery journey, study finds
Cultural differences can have a big impact on mental health recovery provisions, a new study from the University of Nottingham has shown.
Digital health tools stuck in research—new article offers six ways forward
Digital tools such as apps, sensors, and AI-based solutions have become increasingly common in research on lifestyle interventions and self-management for chronic conditions like cardiovascular disease and type 2 diabetes. However, despite encouraging outcomes, few of these tools are actually implemented in everyday health care.
Known risk factors alone do not explain disease accumulation, finds study
As the population ages, multimorbidity, or when a patient has multiple diseases at once, is becoming increasingly common. The onset of one disease increases the risk of developing other diseases, making it necessary to investigate how a range of risk factors together affect such accumulation. Prior studies have focused on individual risk factors and related individual diseases.
Q&A: How cryptic mitochondrial DNA mutations reveal a hidden layer of the aging process
New research published in Nature Communications into hidden mutations in mitochondrial DNA has uncovered how high mutational levels coincide with later life and link to aging markers.
Endolymphatic sac decompression effective for vertigo, migraine
For Meniere disease (MD) patients with migraine, endolymphatic sac decompression (ELSD) is effective, providing postoperative relief of vertigo and migraine, according to a study published online April 30 in Acta Oto-Laryngologica.
Vesicle cycle model reveals inner workings of brain synapse
How do we think, feel, remember, or move? These processes involve synaptic transmission, in which chemical signals are transmitted between nerve cells using molecular containers called vesicles. Now, researchers have successfully modeled the vesicle cycle in unprecedented detail, revealing new information about the way our brain functions.
Comprehensive tumor genome analysis offers blueprint for more effective brain cancer treatments
In the largest ever study of its kind, an analysis of entire tumor genomes has provided the most complete picture yet of an aggressive type of brain cancer.
Alcohol abuse drug may halt trauma-induced cell death, especially in females
Runaway cell death and inflammation triggered by severe trauma may be interrupted by a drug used to prevent alcohol abuse—and it may be particularly effective in females, according to research led by University of Pittsburgh School of Medicine surgeon-scientists and published in Science Translational Medicine.