Epigenetic control vital for proper placental blood vessel development, study finds

If the development of blood vessels in the placenta is impaired, fetal growth retardation may result. Scientists from the German Cancer Research Center (DKFZ) and the Mannheim Medical Faculty of Heidelberg University discovered that the correct development of functioning blood vessels in the mouse placenta is controlled epigenetically: One of the enzymes that modify gene activity using methyl groups is responsible. The researchers also observed a connection with a deficiency of this “methyltransferase” in a well-known pregnancy complication.

The progression from gestational diabetes to type 2: Study discovers biomarker-related genetic predisposition

Among those who have had gestational diabetes, about 35% will develop type 2 diabetes within a decade. A new study led by Dr. Saifur Khan, Ph.D., cardiology research faculty member at the University of Pittsburgh Vascular Medicine Institute, is the first to identify molecular mechanisms of the progression from gestational diabetes to type 2 diabetes.

Breast cancer-related fatigue: The benefits of adapted physical activity

While fatigue is often seen as a hallmark of modern life, the exhaustion experienced by cancer patients is profoundly different. It is not just a symptom but the most frequently reported one, often underestimated in treatment plans. This persistent and debilitating fatigue profoundly affects patients’ quality of life, posing a heavy psychological and physical burden.