Antiviral protein causes genetic changes implicated in Huntington’s disease progression

People genetically susceptible to Huntington’s disease often see their movement, mood, and cognition decline slowly over time. The cause is related to expansion of repeating DNA units, in which specific strings of genetic code—in this case, a series of cytosine-adenine-guanine nucleotides, or CAG, on one strand of the DNA and cytosine-thymine-guanine, or CTG, on the complementary strand—begin to repeat over and over, expanding to as many as 40 to 120 copies.

Science behind genetic testing for identifying risk of opioid misuse remains unproven, says study

Opioid misuse and specifically opioid use disorder (OUD), continues to represent a significant U.S. public health threat, with more than 6 million Americans aged 12 and older meeting the criteria for OUD in 2022. Efforts to ease the crisis have included the development of genetic testing to identify individuals most at risk for OUD.

AI platform identifies which patients are likely to benefit most from a cancer clinical trial

A study led by Winship Cancer Institute of Emory University and Abramson Cancer Center of the University of Pennsylvania researchers demonstrates that a first-of-its-kind platform using artificial intelligence (AI) could help clinicians and patients assess whether and how much an individual patient may benefit from a particular therapy being tested in a clinical trial.