Common anticancer drugs may offer new hope to PTEN Hamartoma Tumor Syndrome patients

During development, cells grow, expand, and migrate to generate tissues and organs in a highly controlled manner. Many intracellular pathways—series of signaling cascades within a cell—regulate these actions to avoid non-programmed growth that could lead to malformations or cancer. One of these pathways is the PTEN / PI3K axis, a complex series of perfectly balanced chemical reactions.

Experimental blood test accurately indicates severity and predicts potential recovery from spinal cord injury

By analyzing DNA and proteins in the blood of people with and without acute spinal cord injuries (SCIs), researchers at the Johns Hopkins University School of Medicine have developed a novel blood test that has the potential to rapidly predict the severity and likelihood of sensory and motor recovery within six months in a cost-effective manner.

New transcatheter valve safe, effective for treating aortic regurgitation

Patients who underwent transcatheter aortic valve replacement (TAVR) with a valve designed to treat aortic regurgitation had an overall mortality rate of just 8.1% at one year, well below the trial’s prespecified goal of 25% to show non-inferiority, according to a study presented at the American College of Cardiology’s Annual Scientific Session (ACC.25).

Stem cell infusion timing can prevent acute graft-versus-host disease

A research team has identified the impact of stem cell infusion timing on the incidence and severity of acute graft-versus-host disease (aGVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT), highlighting the role of the recipient’s circadian rhythms. The team was led by Prof. Zhan Cheng from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences and Chief Physician Zhu Xiaoyu from the Department of Hematology at the First Affiliated Hospital of the University of Science and Technology of China.