Posts in category: Uncategorized

A team of scientists has uncovered the mechanism of cellular uptake for large and polar drugs and devised a novel strategy to optimize the capacity of drug-delivery into these cells. The team was led by Hong-yu Li, Ph.D., professor of medicinal chemistry and chemical biology with the Department of Pharmacology and the Barshop Institute at the University of Texas Health Science Center at San Antonio (UT Health San Antonio), together with teams from Duke University (Duke) and the University of Arkansas for Medical Sciences (UAMS)

A research team has unveiled a crucial mechanism that helps regulate DNA damage repair, with important implications for improving cancer treatment outcomes.

One of the challenges of fighting pancreatic cancer is finding ways to penetrate the organ’s dense tissue to define the margins between malignant and normal tissue. A new study uses DNA origami structures to selectively deliver fluorescent imaging agents to pancreatic cancer cells without affecting normal cells.

Breast cancer is becoming increasingly treatable, but in some cases the disease can resurface even decades after a patient has been declared cancer free. This is because of cells that detach from the original tumor and hide in a dormant state in the breast or other organs.

A preclinical study by scientists at Scripps Research finds that a drug already FDA-approved for treating inflammatory conditions may help reduce both alcohol intake and pain sensitivity—two issues that commonly co-occur with alcohol use disorder (AUD).

There are new findings out about the benefits of eating walnuts. Results from a UConn School of Medicine clinical trial on the cover of the April edition of the journal Cancer Prevention Research show that walnuts improve systemic inflammation while also reducing colon cancer risk.

When receiving a lung transplant, one of the most important complications to look out for is chronic lung allograft dysfunction, known as CLAD. Preventing this complication for those who receive a lung transplant is of the highest priority, as there are no universally effective treatments for CLAD once it is established.

Our brain requires a constant supply of energy. A disrupted energy supply, as, for instance, caused by a stroke, can have serious complications. A team from the research group Cellular Neurobiology at Ruhr University Bochum, Germany, together with researchers from the Universities of Düsseldorf and Twente, investigated how an energy deficiency in the brain affects the release of the neurotransmitter glutamate.

A study by researchers from Emory University’s Rollins School of Public Health and Vanderbilt University Medical Center has found that parental support for adolescent medical consent varied significantly depending on how the question was framed.

A brief episode of anxiety may have a bigger influence on a person’s ability to learn what is safe and what is not. Research recently published in npj Science of Learning has used a virtual reality game that involved picking flowers with bees in some of the blossoms that would sting the participant—simulated by a mild electrical stimulation on the hand.