Wnt pathway dysfunction influences colorectal cancer response to immunotherapy, finds study

Colorectal cancer (CRC) presents with varying clinical characteristics due to tumor heterogeneity. Microsatellite instability (MSI), present in 10–15% of CRC cases, indicates a different clinical trajectory than microsatellite stable (MSS) patients. Notably, MSI patients tend to have better outcomes and respond well to immunotherapy, but not to chemotherapy. The reason behind this disparity and the mechanisms governing MSI remained largely unknown.

Study shows COVID-19 infection alters gene transcription of olfactory mucosal cells in Alzheimer’s disease

A new study identifies alterations in the transcriptomic signatures in human olfactory mucosal cells of individuals with Alzheimer’s disease following SARS-CoV-2 infection, potentially contributing to exacerbated COVID-19 outcomes. The study was conducted at the University of Eastern Finland in collaboration with the University of Helsinki and published in Journal of Neuroinflammation.