‘Reduce and remove’ strategy plus living donor transplant successfully cures terminal liver cancer in patient

A new treatment strategy for locally advanced liver cancer, known as “reduce and remove,” was announced by the Department of Surgery and Department of Clinical Oncology, Center of Cancer Medicine, School of Clinical Medicine, LKS Faculty of Medicine of the University of Hong Kong (HKUMed) earlier this year. This innovative approach provides a way for patients with inoperable locally advanced liver cancer to be cured.

Researchers develop ‘potent and specific’ compounds to curb cancer growth

Proteasomes are protein-degrading complexes that are important for cancer cell survival. Proteasome inhibitors are commonly used to treat diseases such as multiple myeloma and mantle cell lymphoma. Proteasomes have three different active sites but all current FDA-approved inhibitors preferentially target only one active site, known as β5. Despite their success, these drugs have significant limitations including severe side effects and drug resistance.

Research reveals novel ways of cultivating brain cells to treat and study

Scientists from Duke-NUS Medical School and their collaborators have come up with new methods to cultivate brain cells from stem cells to treat and study neurodegenerative diseases. This novel technology forms the basis of two recent research projects under the newly established GK Goh Center for Neuroscience (the GK Goh Center) at Duke-NUS, offering hope for new treatments to patients suffering from neurological conditions such as Alzheimer’s disease, ischemic stroke and Parkinson’s Disease.