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An anonymous San Diego resident has become a fascinating example of how the human immune system fights SARS-CoV-2. In a new investigation, scientists from La Jolla Institute for Immunology (LJI) have shown how antibodies, collected from this clinical study volunteer, bind to the SARS-CoV-2 “Spike” protein to neutralize the virus.

At least half of all autistic children experience some form of aggression, such as hitting, kicking or name-calling, while their parents are tasked with helping them cope and integrate socially. Yet the prevalence and characterization of aggressive behaviors across autistic development are poorly understood.

A new research paper was published in Aging, titled “Characterization of the HDAC/PI3K inhibitor CUDC-907 as a novel senolytic.”

Public health outreach efforts often strive to overcome communication barriers by using interpretation and translation to present information to communities in their native language. However, bilingual people from cultural backgrounds in which mental health is a particularly taboo topic may be more likely to support treatment when they hear information in their second language, said Leigh H. Grant (University of Chicago) about her findings in Clinical Psychological Science.

For 30% to 40% of lymphoma patients who receive CAR T therapy, the treatment is a godsend. Typically given to lymphoma patients for whom other treatments have proven ineffective, CAR T therapy involves removing immune cells from the body via a blood draw, reengineering them to become better cancer fighters, then reintroducing them to the bloodstream, where they seek out and destroy cancer cells.

A new clinical guideline from the American Society for Radiation Oncology (ASTRO) and European Society for Radiotherapy & Oncology (ESTRO) provides guidance on the use of definitive local therapy—including radiation and surgery—to treat patients with oligometastatic non-small cell lung cancer (NSCLC). The guideline is published in Practical Radiation Oncology.

One in five adults in California, or an estimated 6.5 million people, are concerned that someone they know, usually a friend or family member, is at risk of harming themselves or others, according to new research published in Preventive Medicine.

A new approach to chimeric antigen receptor T-cell (CAR T) therapy has shown great promise against small cell lung cancer (SCLC) in a preclinical study. The findings cover new ground in our understanding of how CAR T can be employed against solid-tumor cancers, and provide support for further studies in cancer patients.

Little is known about how radiation therapy to kill cancer cells affects immune cells and other components of patient tumors. But a study out of Roswell Park Comprehensive Cancer Center is shedding light on that process, providing information that could be key for planning treatment regimens that combine immunotherapy and radiation therapy. The authors outline their findings in a new study in the Journal for ImmunoTherapy of Cancer.

A study from Washington University School of Medicine in St. Louis indicates that the COVID-19 mRNA vaccine may be more effective at preventing infections if doses are given around the middle of the day rather than at other times. The researchers believe circadian rhythm—the natural cycle of physical and other changes our bodies go through in a 24-hour period—may affect the body’s response to the vaccine.