First ‘multiome’ atlas of cell development in the human cerebral cortex from before birth to adulthood constructed

A team of researchers from the Icahn School of Medicine at Mount Sinai and Yale University School of Medicine has created the first “multiome” atlas of brain cell development in the human cerebral cortex across six broad developmental time points from fetal development into adulthood, shedding new light on their roles during brain development and disease.

What makes us human? Detailed cellular maps of the entire human brain reveal clues

In a suite of 21 papers published in the journals Science (12), Science Advances (8), and Science Translational Medicine (1), a large consortium of researchers shares new knowledge about the cells that make up our brains and the brains of other primates. It’s a huge leap from previously published work, with studies and data that reveal new insights about our nervous systems’ cellular makeup across many regions of the brain and what is distinctive about the human brain.

Feds hope to cut sepsis deaths by hitching Medicare payments to treatment stats

Sepsis, the body’s extreme response to an infection, affects 1.7 million adults in the United States annually. It stems from fungal, viral, or bacterial infections. Treatment delays of even a few hours can undermine a patient’s chance of survival. Yet sepsis can be difficult to diagnose because some patients don’t present with common symptoms like fever, rapid heart rate, or confusion.

Cannabis intoxication triggers cognitive mechanism of addiction, finds study

New research from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN) at King’s College London and the University of Oxford has found that the main component of cannabis, delta-9-tetrahydrocannabinol (THC), leads to people’s attention being more drawn to other cannabis stimuli when using the drug, which researchers suggest could underpin the cognitive mechanisms behind cannabis use disorder (CUD).

How your blood vessels tolerate high blood pressure

A research group at Lund University has studied how a molecular sensor located in the blood vessel wall, controls how the vessel compensates for high blood pressure. As we age, the sensor deteriorates, which can worsen vascular damage caused by high blood pressure and consequently lead to secondary diseases affecting the heart, brain, or other organs. In mice, the researchers demonstrate that the absence of the sensor leads to the development of aortic aneurysms. Several key findings have also been confirmed in human blood vessels.

Sweeteners may affect your gut biome and raise blood sugar levels

It’s well-known that “full fat” fizzy drinks such as colas, lemonades and energy drinks raise the risk of obesity, heart disease and diabetes. People who have one can or more a day have a 26% increased risk of developing type 2 diabetes. Sugary drinks rapidly increase blood sugar levels and this can lead to tiredness and increased hunger even in people without diabetes.