Targeting autophagy to enhance memory immune responses

Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells. Mice that lacked the longer isoform, RUBCN130, produced more memory B cells in a way that relied on autophagy. These findings provide further insight into the role of Rubicon in autophagy.

Food insecurity for children in Indigenous communities is a crisis that needs to be addressed, researchers say

Dr. Anna Banerji’s ties to the Arctic run deep. She visited for the first time in 1995 to research respiratory syncytial virus (RSV) in Inuit babies. In 2004, she adopted an Inuit son and developed a close relationship with his foster and biological families. As a tropical disease specialist, infectious disease physician and pediatrician, she was originally looking into RSV vaccine access, but over time and more than 50 visits, another glaring issue in Northern communities became obvious: the lack of food security so many families—and particularly children—face.

Study evaluates protein that regulates pigment cell development for role in skin cancer

The microphthalmia-associated transcription factor (MITF) is the master regulator of pigment cell development and, as a lineage survival oncogene, plays a crucial role in the skin cancer melanoma and its resistance to therapy. How MITF distinguishes between its seemingly incompatible differentiation and proliferation-associated targets in the genome has been a bit of a puzzle.

POWER, MUZA OUT 

By MICHAEL MIYOBA 

ZAMBIAN Champions Power Dynamos have been eliminated form the CAF Champions League after a 3-3 aggregate stalemate against Tanzanian champions Simba Sports Club who were fortunate to march on to the group stage thanks to an away goal rule.

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Govt. calls for urgent formulation of policies for clean energy

NORTH-WESTERN Province Permanent Secretary Grandson Katambi has called for the urgent formulation of policies that will ensure all financial investments in Zambia promote agroecology and clean energy.

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