One of the remaining mysteries of immunology is the exact mechanism that B cells use to generate millions of antibodies with different specificities to protect us from the plethora of pathogens in the environment.
Phase I clinical trial shows treatment designed to clear senescent cells in Alzheimer’s disease is safe
Alzheimer’s disease is the most common cause of dementia that affects more than 6.5 million Americans, according to the Alzheimer’s Association. To find effective treatments and slow the progression of this debilitating disease, researchers have made much progress in developing new drugs that target beta-amyloid plaques, one of the hallmarks of Alzheimer’s disease.
Specialized T cells in the brain found to slow progression of Alzheimer’s disease
As many as 5.8 million Americans are currently living with Alzheimer’s disease, a neurodegenerative condition associated with progressive cognitive decline, including loss of memory capabilities. Protein aggregates, composed of beta-amyloid or other proteins, form in the brains of individuals with Alzheimer’s.
Online AI-based test for Parkinson’s disease severity shows promising results
An artificial intelligence tool developed by researchers at the University of Rochester can help people with Parkinson’s disease remotely assess the severity of their symptoms within minutes. A study in npj Digital Medicine describes the new tool, which has users tap their fingers 10 times in front of a webcam to assess motor performance on a scale of 0–4.
HEED ADVICE
GOVERNMENT must get to grips with the self-created incumbrances in the agriculture sector which is putting the country’s food security at risk.
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Synthetic heparanase inhibitors: Research team develops alternative method for the treatment of herpes
Herpes is not only unpleasant but it can, in some cases, also have dangerous complications and life-threatening consequences. In the journal Angewandte Chemie, a research team has now introduced a completely new approach for treating herpes. Their method is based on the inhibition of an enzyme that is needed for the release of newly formed virus particles from infected cells.
Philips says settles US claims over respirator recall
Philips said Thursday it had clinched a deal in the United States to settle claims related to a recall of sleep respirators that rocked the Dutch medical tech firm.
AI uncovers bias in dermatology training tools
Skin diseases do not look the same across the skin-tone spectrum, and medical textbooks and presentations used to train dermatologists often lack example images of darker skin tones. During the recent pandemic, for instance, studies showed annotated photos of COVID-19’s dermatologic symptoms lacked adequate representation of darker tones.
New research reveals close connection between cognitive flexibility and neurogenesis
The ability to shift from one type of cognitive problem-solving strategy to another when the circumstances change, called cognitive adaptability or flexibility, is an essential function for humans. When this ability is diminished—whether by aging, disease, trauma, or environmental exposure—mental behavior becomes more inflexible and a person has difficulty adapting to new cognitive demands and remains stuck in the previous way of thinking.
Researchers show zinc plays a key role in inflammatory bowel disease and ‘leaky gut’
New research, published in Nature Communications, has found that a link between the important micronutrient zinc and a sensor protein in the gut in the prevention and management of a range of bowel conditions, such as inflammatory bowel disease (IBD).