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Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS). In Germany, more than 280,000 people are affected. In most cases, MS progresses in relapses, which occur completely irregularly as excessive inflammatory reactions in the spinal cord and brain. In the process, misdirected immune cells destroy the protective myelin sheaths of the nerve fibers and thus damage the nerves.

…. As it attracts K5.1bn worth of nominal bids

By BUUMBA CHIMBULU

ZAMBIA has for the second month recorded surging interest in its government paper as it attracts K5.1 billion worth of nominal bids in its fixed income sale held last Friday.

Offshores have also continued to remain bullish on its long-term outlook.

The country attracted K5.1 billion worth of nominal bids in its fixed income sale held last Friday, for which the Bank of Zambia (BoZ) accepted K4.6 billion worth of nominal appetite.

According to the Kwacha Arbitrageur, Zambia’s bonds were a good carry trade given the current yields in the 20’s that most players seeking to house their liquidity.

“Friday’s bond auction revealed a strong appetite skew on the longer end of the yield curve with close to K3.6 billion of the bids in the 10 – 15-year tenors paying 26.75 percent and 27.75 percent respectively.

“The Kwacha term structure of interest rates remained unchanged as yields exhibit stickiness upwards due government financing shortfalls. For local players, the current bond yields provide decent cover and compensation for the inflation levels at 10.3 percent making real yields positive,” the magazine stated.

It indicated that in the middle of a debt restructure, Zambia continued to attract confidence in its economic recovery process that had attracted global money looking for a home in a safe jurisdiction.

“Despite delays in the restructure process marred by completion of signing of memoranda of understanding a key determinant of the private debt reorganisation process, investors are more optimistic than ever concerning the sovereign posture improvement of the copper producer,” the magazine indicated.

The magazine indicated that Moody’s rating agency recently upgraded Zambia’s local currency long term issuer rating to Caa3 from Ca due to the strides the sovereign has taken to earn it bilateral debt treatment.

However, the rating agency cited weak governance, cash flow position and exposures to environmental headwinds (impacting agribusiness and energy generation) continue to weigh.

Zambia continues to grapple with foreign exchange risk as dollar supply concerns persistent causing demand backlogs.

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Expert advice on nutrition delivered to patients electronically saved physicians time, improved patient satisfaction, and was reimbursable by insurance, UT Southwestern Medical Center researchers report. The findings, published in Nutrients, showcase a new model developed at UT Southwestern to feed the growing interest among patients in learning how food can affect their health.

High levels of exposure to the virus that causes COVID-19 may reduce or overcome the protection that vaccination and prior infection provides, according to a new study by researchers from Yale University, the University of Florida, and the Connecticut Department of Correction.

A new study led by McGill University examines why people living in Atlantic regions are more at-risk for developing melanoma than other Canadians, providing lessons on skin cancer prevention for the whole country.

To improve therapies for cancer and other diseases, researchers strive to identify tissue-specific therapeutic targets and diagnostic biomarkers in every patient. Identifying specific targets and biomarkers can be achieved by analyzing the cellular composition of tumors at the single-cell level. Although tissue profiling technologies such as single-cell RNA and single-nuclei RNA sequencing provide cell-type-specific information at unprecedented resolution, their implementation has technical and financial challenges that prevent their widespread adoption in clinical settings.

While prior research and analysis have evaluated methods of outpatient labor induction (also known as cervical ripening), the specific approach with the highest efficacy and safety remains uncertain. More than a quarter of all labors in the United States required induction in 2018, according to the National Center for Health Statistics, and will likely continue to rise in the future. A new study by Mount Sinai researchers, published in the American Journal of Obstetrics and Gynecology, aims to identify the most effective and safest cervical ripening strategy.

A new study by Indiana University School of Medicine researchers uses more genetically diverse mouse models to study the accumulation and spread of abnormal tau protein deposits in the brain—a known sign of Alzheimer’s disease and several other neurodegenerative diseases. The study’s findings, recently published in the Journal of Experimental Medicine, could lead to better research models that improve understanding of how different genetic backgrounds influence neurodegenerative disease development and treatment needs.

Researchers report a statistically significant and clinically important increase in heat related illnesses among patients at US Department of Veteran Affairs (VA) health facilities across the United States between 2002 and 2019. The study, which appears in The Journal of Climate Change and Health, documents far-reaching negative consequences of extreme-weather.

For adults with moderate-to-severe atopic dermatitis (AD), dupilumab treatment yields significant improvement in sleep quality and other AD-related signs and symptoms, according to a study published online Aug. 10 in the British Journal of Dermatology.