Brain channels ‘stopped in time’ reveal chemical flow that enables learning and thinking

In an effort to understand how brain cells exchange chemical messages, scientists say they have successfully used a highly specialized microscope to capture more precise details of how one of the most common signaling molecules, glutamate, opens a channel and allows a flood of charged particles to enter. The finding, which resulted from a study led by Johns Hopkins Medicine researchers, could advance the development of new drugs that block or open such signaling channels to treat conditions as varied as epilepsy and some intellectual disorders.

Clinical trials show new antibody therapy offers long-lasting HIV control without daily medication

If the past four decades have taught us anything about HIV, it’s to adjust our expectations—despite enormous progress in controlling the virus, no treatment can yet completely eradicate HIV once it has taken hold. But promising results from a recent clinical trial suggest that broadly neutralizing antibody therapy (bNAbs) may be able to accomplish the next best thing.

Nasal protein could aid in early COPD detection

Early diagnosis of COPD, chronic obstructive pulmonary disease, increases the quality of life of the patient and the efficacy of available treatments. Researchers at Karolinska Institutet have now shown that material from nasal lavage provides a basis for assessing COPD. The study, which has been published in the Journal of Allergy and Clinical Immunology, could lead to a simple diagnostic method for early assessment of COPD.

Everyday physical activity does not slow bone loss during menopause, finds study

According to a recent study from the University of Jyväskylä, Finland, the impacts of everyday physical activity do not attenuate the accelerated hormonal bone loss that occurs during menopause. Effective bone-loading impacts are rare in everyday life. Future research should explore whether more targeted exercise can slow menopausal bone loss. The study suggests that impacts accumulated during everyday life are not sufficient to slow hormonal bone loss during menopause.