Clinical trial shows cancer-preventing topical immunotherapy trains immune system to fight precancers

A new study by investigators from Mass General Brigham uncovers how a novel immunotherapy prevents squamous cell carcinoma, with benefits lasting five years after treatment. This therapy is the first to activate specific components of the adaptive immune system, particularly CD4+ T helper cells, which are not known to be involved in traditional cancer treatments.

Discovery of ‘pliancy genes’ showcases role of latent epigenetic programs in retinal recovery 

The retina is a dynamic tissue of the eye made up of many different types of cells. Scientists at St. Jude Children’s Research Hospital used single-cell sequencing techniques to study retinal cells called Müller glia, showing that these cells have a unique set of “pliancy genes” that are open and accessible to gene expression machinery without being expressed.