Variable patient responses to SARS-CoV-2 infection are mimicked in genetically diverse mice

Researchers at The Jackson Laboratory have created a panel of genetically diverse mice that accurately model the highly variable human response to SARS-CoV-2 infection. Together with collaborators at NIH’s Rocky Mountain Laboratories, the team uncovered differences in the innate immune and regulated proinflammatory responses, the timing and strength of which are associated with disease severity.

Study shows immunotherapy may benefit a subset of patients with penile cancer

Penile cancer is a rare disease with approximately 2,070 new cases each year in the U.S. Treatment options are limited and typically begin with platinum chemotherapy. Immune checkpoint inhibitors (ICIs) are novel therapies that are active in several cancer types but are understudied in penile cancer. Clinical trials to evaluate ICIs for penile cancer are challenging to run because the cancer is so rare.

‘SACRED COW’

GOVERNMENT must put a stop to what is now becoming an annual charade at the Ministry of Agriculture involving the supply and distribution of fertiliser.

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Power Dynamos geared up

…Zambian champions ready to make the country proud, says Chipepo

By MICHAEL MIYOBA

POWER Dynamos coach Mwenya Chipepo says the Zambian champions are ready to make the country proud in the CAF Champions League where they will meet African Stars FC of Namibia in the preliminary round.

Chipepo said the Kitwe giants are also ready to defend the FAZ Super League set to resume tomorrow.

In an interview yesterday, Chipepo said Power Dynamos had prepared adequately for the new season which he predicted will be very tough.

“We are prepared, we are ready for the league and also we are ready to compete in the CAF Champions League where we are meeting Namibian champions so we have prepared the team very well and we are ready,” Chipepo said.

“If you watched the game we played in Tanzania against Simba, though it has been long since we competed at that level, the boys showed character and played good football under a big crowd although there is room for improvement, but we are ready,” he said.

Chipepo named former Champions Red Arrows and Ndola giants Zesco United as one of the teams that will give Power Dynamos stiff competition in the new season.

“The league will be tougher than last season because everyone knows that Power Dynamos will be the team to beat. 

Everyone who will be coming to play us they will be coming prepared so it is just a matter of making sure that we work even harder than we did last season. It is not going to be easy. 

We know our players have improved and I have seen some teams like Red Arrows, teams like Zesco United, I’ve seen the way they’ve prepared themselves through the four-team tournament so it is not going to be easy. We just have to work extra hard,” he said.

Power Dynamos will begin the new season with a clash against Forest Rangers in tomorrow’s Samuel ‘Zoom’ Ndlovu Charity Shield before playing African Stars on August 19 in Namibia.

Chipepo warned that it would be dangerous for the Zambian champions to underrate Forest Rangers as the two sides prepare to face off in a match where the fans will dictate the players to feature on either team.

Playing football may increase the risk for Parkinson’s disease

Identification of risk factors for Parkinson’s disease (PD) is essential for early diagnosis. Dating back to the 1920s, Parkinson’s disease and parkinsonism—an umbrella term that refers to motor symptoms found in Parkinson’s disease and also other conditions—have long been described in boxers. Repetitive head impacts from tackle football can also have long-term neurological consequences like chronic traumatic encephalopathy (CTE). But research on the association between participation in tackle football and PD is limited.