Mechanism facilitates brain metastasis from breast cancer and melanoma by inducing neuroinflammation

In a new study from Tel Aviv University published in the journal Nature Cancer, a team of researchers led by Prof. Neta Erez, head of the laboratory for the biology of tumors from the Department of Pathology at the Sackler Faculty of Medicine, identified and characterized a new mechanism that facilitates the formation of brain metastases and found that impairing this mechanism significantly reduced the development of brain metastases in mice.

UPND in Lungu-phobia – Kalaba

By NATION REPORTER

FORMER president Edgar Lungu seems to have become such a threat to the UPND that they have developed such a profane phobia that they wish they could have him completely confined and gagged from commenting on any national matter, Harry Kalaba has said.

And Raphael Nakacinda says former President Lungu has been uniquely magnanimous to allow President Hakainde Hichilema and the UPND to govern without any form interference by keeping away from politics and the maladministration that have become characteristic under them.

Mr Kalaba, the president of Citizen’s First Party says it is surprising that each time former President Lungu appeared in public, the UPND were politically convulsing and quivering with knee-jerk reactions.

Mr Kalaba said the behaviour by the UPND attacking former President Lungu for only asking the price of mealie meal and rice was uncalled for and an act of inadequacy on the part of the governing party.

Last week, the UPND attempted to gag Mr Lungu by banning his from making public appearances, claiming that the former head of State was throwing political innuendoes at his successor, President Hichilema. 

On Monday, the UPND secretary general, Batuke Imenda claimed former President Lungu was shadow-boxing with President Hichilema and should therefore come out and declare himself politically active.

But Mr Kalaba said he did not see anything wrong with Mr Lungu making public appearances and commenting on national matters such as the prices of commodities like mealie meal.

“The UPND should leave President Lungu alone to enjoy his retirement. Former President Lungu is a Zambian, a citizen with all the rights. Who told the UPND that when you retire from politics, then you lose your rights to comment on national matters? It seems the UPND are so scared about former President Lungu because of their monumental failure to gover…otherwise they would not be suffering from Lungu-phobia. Let them accept that when one retires, it does not mean he cannot give an opinion on the governance of the country,” Mr Kalaba said.

Mr Kalaba advised that the UPND leadership should stop the vengeance, hatred, retribution and vindictiveness and concentrate on delivering on the promises they had made to Zambians.

He said former President Lungu did not commit any crime by asking how much mealie meal was costing and wondered why the UPND leadership was seeing innuendoes in such an innocent inquiry.

“The former President is not under house arrest. He is not in Lamara where Yasser Arafat was under house arrest. Let the UPND leave Mr Lungu alone to enjoy his retirement,” Mr Kalaba said.

And Mr Nakacinda said the phobia that the UPND were exhibiting each time former President Lungu appeared in public was worrying because the former head of State was not under house arrest.

 Mr Nakacinda advised UPND secretary general Batuke Imenda to censure himself when issuing statements about the former president because they are not on the same level.

“A mature politician should be able to gauge the level of the person they are talking to and the issues they are labeling against him,” he said.

He said Mr Lungu was at liberty to engage the members of the public especially that he runs a foundation and various organizations go to him for wisdom on how society should be governed.

Mr Nakacinda said the UPND should be at peace because the only defense they have for now was to fulfil the promises they made to the people of Zambia.

Researchers discover key role of DNA methylation in Alzheimer’s disease

Mount Sinai researchers have published a study in Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association that sheds new light on the role of DNA methylation in Alzheimer’s disease (AD). The study found that DNA methylation has a profound impact on gene and protein co-expression networks associated with AD and could lead to the discovery of new neuropathological processes and molecular mechanisms for developing novel treatments for the disease.

Gov’t urged to realign policies to uplift youths’ welfare

By MILLENNIUM REPORTER
PATRIOTIC Front (PF) Presidential hopeful Greyford Monde says, there is need to realign policies in the country in order to uplift the welfare of the youths in the country.
Speaking when he featured on Millennium TV programme dubbed “The common room, Mr Monde said, nothing much has been done to support the youth which has resulted in them languishing in poverty.
Mr Monde said, despite the new dawn administration promising jobs and empowerment to the youths, it has failed to fulfill the promise.

It was wrong for Findlay to have more than one passport – Witness

A NATIONAL Registration Passport and Citizenship, assistant registration officer, has told the Lusaka Magistrate court that it was wrong for Lusaka business executive, Harry Findlay to hold more than one passport.
Mr. Mulenga Kaliwile said this was because Findlay had reported to the office that his passport was lost when he went to obtain a new passport.
He told Lusaka Principal Magistrate Sylvia Munyinya during cross examination yesterday that Findlay obtained another passport because the one he had got was lost and he needed another one. Findlay is charged with two counts of holding more than one passport and found with endorsements of forged immigration stamps.
It is alleged that Findlay on March 14 2017, at Lusaka did acquire a Zambian ZPO21382 passport number purporting to have lost a Zambian passport number ZPO13259 when in fact not.
In the second counts, Findlay is alleged to have being found with a forged immigration endorsements of forged immigration stamp in a passport found in possession of endorsements of forged immigration stamps for Mwami Immigration Border Control in his passport number ZPO32178 purporting to show that it was officially endorsed when in fact not. But during cross examination led by one of the defence lawyers, Milner Katolo, when asked if there was anything wrong with Findaly holding more than one passport, Mr Kaliwile said there was wrong because when he obtained Zambian ZPO21382 he had lost his Zambian passport number ZPO13259.
He insisted when asked by Mr Katolo what was wrong with Findlay having passports which were regularly issued to him by the passport office that there was something wrong because the records indicated that his earlier passport no .ZPO13259 got lost.
Mr Kaliwile explained that once a passport was reported missing and replaced it was not supposed to continue being used.
Further, in cross examination by another defence lawyer, Charles Changano, Mr Kaliwile agreed that a passport was only issued to a person when they met the requirements and the passport office was satisfied.
He said that upon being issued with the passport, both the passport officer and passport holder were supposed to sign to confirm that everything was in order.
He further explained that he never signed any of Findlay’s passports but were signed by a Mr Nkhoma who was now deceased. He agreed in continued cross examination by defence lawyer Jonas Zimba that he did not tell the immigration that previous passports which were issued to Findlay were not cancelled. Trial continues on March 3, 2023