Methionine restriction observed to reverse old-age obesity in mice

Obesity increases with aging. Methionine restriction affects lipid metabolism and can prevent obesity in mice. In a new study published in the journal Aging, researchers from AntiCancer Inc., University of California San Diego and Showa University School of Medicine observed C57BL/6 mice double their body weight from 4 to 48 weeks of age and become obese. The team then evaluated the efficacy of oral administration of recombinant-methioninase (rMETase)-producing E. coli (E. coli JM109-rMETase) or a methionine-deficient diet to reverse old-age-induced obesity in C57BL/6 mice.

Brain imaging-based biomarker of depression identified

Major depressive disorder (MDD) is not only among the most common mental illnesses, affecting more than 8% of Americans, but it is also extremely variable from one person to another. Researchers have recently begun making strides toward understanding the neurophysiology underlying different subtypes of depression, which could speed development of better treatments, but much remains to be discovered.